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This review provides detailed comparisons of epidemiology, genetic predispositions, clinical features, risk factors of hepatocellular carcinoma, and mortality in <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients between eastern and western countries. <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> prevalence and incidence are lower in <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sia\u2010<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>acific area than in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>urope and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merica. <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican patients seem to have more severe disease, characterized with human leukocyte antigen\u2010<jats:styled-content style=\"fixed-case\">DR<\/jats:styled-content>3 haplotype, younger age, more <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content>\u2010induced \u201ccirrhosis\u201d at diagnosis, higher elevated serum immunoglobulin <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content> levels, and positive rate of antisoluble liver antigen\/liver pancreatitis. The overall <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> diagnostic accuracy of revised original criteria and simplified scoring system are similar in <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean\/<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>merican populations and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sian. Cirrhosis at presentation and non\u2010response to immunosuppressive therapy within 1 year are the most important predictors for poor prognosis of <jats:styled-content style=\"fixed-case\">AIH<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/jgh.12952","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T06:51:39Z","timestamp":1426229499000},"page":"1230-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Autoimmune hepatitis: East meets west"],"prefix":"10.1111","volume":"30","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Cancer Institute Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qixia","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Cancer Institute Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaolian","family":"Bian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Cancer Institute Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin\u2010Lin","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Cancer Institute Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidong","family":"Jia","sequence":"additional","affiliation":[{"name":"Liver Research Center &amp; Clinical Epidemiology and EBM Unit Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncogenes and Related Genes Key Laboratory of Gastroenterology &amp; Hepatology Ministry of Health Division of Gastroenterology and Hepatology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Cancer Institute Shanghai Institute of Digestive Disease  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.06019.x"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802130183"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.10.020"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06384.x"},{"key":"e_1_2_2_6_1","first-page":"602","article-title":"Profiles of autoimmune hepatitis in Brunei Darussalam","volume":"8","author":"Jalihal A","year":"2009","journal-title":"Hepatobiliary Pancreat. 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