{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:35:14Z","timestamp":1789526114104,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>We have previously found high incidence of inflammatory bowel disease (IBD<\/jats:styled-content>) in A<\/jats:styled-content>ustralia. A population\u2010based registry was established to assess disease severity, frequency of complications, and prognostic factors.<\/jats:p><\/jats:sec>Methods<\/jats:title>Incident cases were prospectively identified over 4 years. Early disease severity was assessed according to need for hospitalization and resective surgery and medication use.<\/jats:p><\/jats:sec>Results<\/jats:title>We report on the early outcomes (median 18 months, range 12\u201360 months) for 252 patients comprising 146 with C<\/jats:styled-content>rohn's disease (CD<\/jats:styled-content>), 96 with ulcerative colitis (UC<\/jats:styled-content>), and 10 IBD<\/jats:styled-content> undifferentiated. Eighty\u2010seven percent of CD<\/jats:styled-content> patients had inflammatory disease at diagnosis, and this reduced to 73% at 5 years (n<\/jats:italic>\u2009=\u200938). Immunomodulators were prescribed in 57% of CD<\/jats:styled-content> patients and 19% with UC<\/jats:styled-content>. A third of all CD<\/jats:styled-content> patients were hospitalized, the majority (77%) in the first 12 months. Risk factors for hospitalization included penetrating, perianal, and ileocolonic disease (P<\/jats:italic>\u2009<\u20090.05). Twenty\u2010four percent of UC<\/jats:styled-content> patients were hospitalized, most within the first 12 months. Intestinal resection rates were 13% at 1 year in CD<\/jats:styled-content> and 26% at 5 years. Risk factors include penetrating and stricturing disease (P<\/jats:italic>\u2009<\u20090.001) and ileal involvement (P<\/jats:italic>\u2009<\u20090.05). Colectomy rates in UC<\/jats:styled-content> were 2% and 13% at 1 and 5 years. High C<\/jats:styled-content>\u2010reactive protein (CRP<\/jats:styled-content>) at diagnosis was associated with colectomy.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>A high rate of inflammatory disease, frequent immunomodulator use in CD<\/jats:styled-content>, and a low rate of surgery in both CD<\/jats:styled-content> and UC<\/jats:styled-content> were identified. In CD<\/jats:styled-content>, ileal involvement and complex disease behavior are associated with a more severe disease course, while in UC<\/jats:styled-content> a high CRP<\/jats:styled-content> predicted this outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12967","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T10:16:47Z","timestamp":1428920207000},"page":"1346-1353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Prospective population\u2010based cohort of inflammatory bowel disease in the biologics era: Disease course and predictors of severity"],"prefix":"10.1111","volume":"30","author":[{"given":"Olga","family":"Niewiadomski","sequence":"first","affiliation":[{"name":"Gastroenterology St Vincent's Hospital Fitzroy Victoria 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