{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:26Z","timestamp":1772160686043,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Rifaximin has been used for prevention of recurrence of hepatic encephalopathy in twice a day dosage. The drug is expensive and lower dising may be possible.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To determine the efficacy of rifaximin once a day dose in the prevention of hepatic encephalopathy (\n HE<\/jats:styled-content>\n ) in patients with liver cirrhosis as compared with twice daily dose of rifaximin.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This\n R<\/jats:styled-content>\n andomized control trial was carried out at the\n D<\/jats:styled-content>\n epartment of\n G<\/jats:styled-content>\n astroenterology and\n H<\/jats:styled-content>\n epatology,\n S<\/jats:styled-content>\n hifa\n I<\/jats:styled-content>\n nternational\n H<\/jats:styled-content>\n ospital,\n I<\/jats:styled-content>\n slamabad,\n P<\/jats:styled-content>\n akistan from\n N<\/jats:styled-content>\n ovember 2012 to\n F<\/jats:styled-content>\n ebruary 2014. Patients with known chronic liver disease with at least one episode of HE in the past were randomized to group A (rifaximin 550\u2009mg\n OD<\/jats:styled-content>\n ) and group B (rifaximin 550\u2009mg\n BD<\/jats:styled-content>\n ), after fulfilling the inclusion criteria. Each patient was followed for 6 months for any episode of\n HE<\/jats:styled-content>\n . Patients in each group were identified for any breakthrough episode of encephalopathy during this period. Data were analyzed using\n SPSS<\/jats:styled-content>\n version 16. Chi\u2010squared test and\n t<\/jats:italic>\n \u2010test were applied where required to determine the significant difference between the two groups.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were a total of 306 patients: 128 patients in Group A while 178 in group B. Majority of patients (75.81%) had hepatitis C virus with mean age of 52.30\u2009\u00b1\u20099.92,\n MELD<\/jats:styled-content>\n score 13.58\u2009\u00b1\u20098.3, and 55.22% were in Child\u2013Pugh B. Eighty\u2010one patients had an episode of HE during the study period. There were 27 patients in group A and 54 patients in group B with breakthrough episode of\n HE<\/jats:styled-content>\n (\n P\u2009=<\/jats:italic>\n \u20090.088).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study suggests that there is no significant difference in rifaximin once a day or twice daily dose in preventing\n HE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgh.12970","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T06:17:04Z","timestamp":1428905824000},"page":"1420-1422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of once a day rifaximin to twice a day dosage in the prevention of recurrence of hepatic encephalopathy in patients with chronic liver disease"],"prefix":"10.1111","volume":"30","author":[{"given":"Nasir","family":"Khokhar","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Shifa International Hospital Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Omar","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shifa International Hospital Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafiq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shifa International Hospital Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiza","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shifa International Hospital Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamza Hassan","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shifa International Hospital Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farzana","family":"Shafqat","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shifa International Hospital Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Salih","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shifa International Hospital Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)32137-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708143370707"},{"key":"e_1_2_5_4_1","first-page":"495","article-title":"Chronic liver disease related mortality pattern in Northern Pakistan","volume":"13","author":"Khokhar N","year":"2003","journal-title":"J. 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