{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:17:25Z","timestamp":1767827845900,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AstraZeneca Korea Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>This study aimed to validate the equivalence of first\u2010line concomitant and hybrid regimens for <jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter pylori<\/jats:italic> infection in an era of increasing antibiotic resistance. The study also aimed to assess regimen compliance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009pylori<\/jats:italic>\u2010infected patients from six hospitals in Korea were randomly assigned to either concomitant or hybrid regimens. The concomitant regimen consisted of 20\u2009mg of esomeprazole, 1\u2009g of amoxicillin, 500\u2009mg of clarithromycin, and 500\u2009mg metronidazole, twice daily for 10 days. The hybrid regimen consisted of a 5\u2010day dual therapy (20\u2009mg of esomeprazole and 1\u2009g of amoxicillin, twice daily) followed by a 5\u2010day quadruple therapy (20\u2009mg of esomeprazole, 1\u2009g of amoxicillin, 500\u2009mg of clarithromycin, and 500\u2009mg of metronidazole, twice daily).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eradication rates for concomitant and hybrid therapy were 78.6% (187\/238) and 78.8% (190\/241) in the intention\u2010to\u2010treat analysis, and 89.8% (176\/196) and 89.6% (181\/202) in the per protocol analysis. For both analyses, 95% confidence intervals fell within the \u00b1\u20098% equivalence margin. Adherence was better in the hybrid group (95.0%) than in the concomitant group (90.1%), a difference that was borderline significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.051). Adverse event rates were higher in the concomitant group than in the hybrid group for nausea (15.8% <jats:italic>vs<\/jats:italic> 8.8%; <jats:italic>P<\/jats:italic>\u2009=\u20090.028) and regurgitation (17.6% <jats:italic>vs<\/jats:italic> 10.7%; <jats:italic>P<\/jats:italic>\u2009=\u20090.040).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As compared with concomitant therapy, hybrid therapy offered similar efficacy, better compliance, and fewer adverse events. Hybrid therapy could be a reasonable first\u2010line treatment option for <jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>.\u2009pylori<\/jats:italic> in areas with high antibiotics resistance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12983","type":"journal-article","created":{"date-parts":[[2015,4,13]],"date-time":"2015-04-13T06:30:59Z","timestamp":1428906659000},"page":"1361-1366","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Concomitant and hybrid therapy for <scp><i>H<\/i><\/scp><i>elicobacter pylori<\/i> infection: A randomized clinical trial"],"prefix":"10.1111","volume":"30","author":[{"given":"Jun","family":"Heo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Kyungpook National University Hospital  Daegu 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Hepatology Department of Internal Medicine Catholic University of Daegu School of Medicine  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Daegu Fatima Hospital  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Hun","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Dongguk University Gyeongju Hospital  Gyeongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Bae","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Internal Medicine Dongguk University Gyeongju Hospital  Gyeongju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung 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