{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:58:50Z","timestamp":1787885930135,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Gastric cancer develops due to atrophic gastritis induced by H<\/jats:italic><\/jats:styled-content>elicobacter pylori<\/jats:italic> (H<\/jats:italic><\/jats:styled-content>.\u2009pylori<\/jats:italic>) infection. Serum levels of pepsinogen (PG<\/jats:styled-content>) are known to be excellent markers for evaluating the degree of atrophic gastritis. We investigated whether chronic gastritis could be diagnosed by evaluating serum PG<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 4483 patients (average age, 49.7 years; 2879 men) were included in this study. Fasting serum samples were collected and anti\u2010H<\/jats:italic><\/jats:styled-content>.\u2009pylori<\/jats:italic> antibody and PG<\/jats:styled-content> levels were evaluated. We evaluated the endoscopic atrophy grade or histological extent of gastritis, and calculated the diagnostic capability of this serum marker.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 4483 patients, were diagnosed as being positive (4160) or negative (323) for H<\/jats:italic><\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010induced gastritis. In patients with H<\/jats:italic><\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010induced gastritis, the PG II<\/jats:styled-content> levels were higher and the PG I<\/jats:styled-content>\/II<\/jats:styled-content> ratios were lower than among those without H<\/jats:italic><\/jats:styled-content>.\u2009pylori<\/jats:italic> gastritis. A cut\u2010off values of (i) PG I<\/jats:styled-content>\/II<\/jats:styled-content> \u2264\u20095; (ii) PG II<\/jats:styled-content> \u2265\u200910 or PG I<\/jats:styled-content>\/II<\/jats:styled-content> \u2264\u20095; (iii) PG II<\/jats:styled-content> \u2265\u200912 or PG I<\/jats:styled-content>\/II<\/jats:styled-content> \u2264\u20094.5 showed high sensitivity and accuracy (over 90%) for diagnosing H<\/jats:italic><\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010induced gastritis. Moreover, in a mass screening of healthy subjects, a cut\u2010off value of PG I<\/jats:styled-content>\/II<\/jats:styled-content> \u2264\u20094.5 might be better for diagnosing the presence of gastritis because of a sensitivity and specificity >\u200980%.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The presence of H<\/jats:italic><\/jats:styled-content>.\u2009pylori<\/jats:italic>\u2010induced gastritis can be evaluated using serum PG<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12987","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T09:35:09Z","timestamp":1431596109000},"page":"1473-1477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Diagnosis of H<\/i><\/scp>elicobacter pylori<\/i>\u2010induced gastritis by serum pepsinogen levels"],"prefix":"10.1111","volume":"30","author":[{"given":"Yoko","family":"Kitamura","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Health Service Center Hiroshima University Higashi\u2010Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Boda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiji","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kotachi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Hiroshima University Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hiroshima 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