{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:09:08Z","timestamp":1789927748903,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Inhibition of angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> synthesis seems to decrease hepatocellular carcinoma recurrence after radical therapies; however, data on the adjuvant role of angiotensin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor 1 blockers (sartans) are still lacking. The aim of the study was to evaluate whether sartans delay time to recurrence and prolong overall survival in hepatocellular carcinoma patients after radiofrequency ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 153 patients were reviewed. The study population was classified into three groups: 73 (47.8%) patients who received neither angiotensin\u2010converting enzyme inhibitors nor sartans (group 1), 49 (32%) patients treated with angiotensin\u2010converting enzyme inhibitors (group 2), and 31 (20.2%) patients treated with sartans (group 3). Survival outcomes were analysed by means of <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>aplan\u2013<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>eier analysis and compared with log\u2013rank test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the whole study population, 85.6% of patients were in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hild\u2013<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ugh <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> class and 89.6% in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arcelona <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>linic <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>iver <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ancer <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> stage. Median maximum tumor diameter was 30\u2009mm (10\u201340) and alpha fetoprotein was 25 (1.1\u20132100) UI\/mL. No differences in baseline characteristics among the three groups were reported. Median overall survival was 48 months (95% confidence interval: 31\u201358) in group 1, 72 months (49\u201389) in group 2, and 84 months (58\u201392) in group 3 (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Median time to recurrence was 26 (15\u201342), 44 (33\u201372), and 69 (44\u201374) months in the three groups, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). Sartan therapy was a significant predictor of longer overall survival and delayed time to recurrence on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sartans significantly improved overall survival and time to recurrence after radiofrequency ablation in hepatocellular carcinoma patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12988","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T09:35:20Z","timestamp":1431596120000},"page":"1643-1650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Angiotensin receptor blockers improve survival outcomes after radiofrequency ablation in hepatocarcinoma patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Antonio","family":"Facciorusso","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Del Prete","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Crucinio","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Muscatiello","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Medical and Surgical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian I","family":"Carr","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Tumor Biology National Institute for Digestive Diseases IRCCS \u201cSaverio de Bellis\u201d  Castellana Grotte Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Di Leo","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Emergency and Organ Transplantation University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Barone","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Department of Emergency and Organ Transplantation University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1001683"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2343040350"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23181"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12618"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.905626"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i47.8895"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21415"},{"issue":"5","key":"e_1_2_5_11_1","article-title":"STORM: a phase III randomized, double\u2010blind, placebo\u2010controlled trial of adjuvant sorafenib after resection or ablation to prevent recurrence of hepatocellular carcinoma (HCC)","volume":"32","author":"Bruix J","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.011"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04663.x"},{"key":"e_1_2_5_14_1","first-page":"1547","article-title":"Combination of branched\u2010chain amino acids and angiotensin\u2010converting enzyme inhibitor suppresses the cumulative recurrence of hepatocellular carcinoma: a randomized control trial","volume":"26","author":"Yoshiji H","year":"2011","journal-title":"Oncol. Rep."},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0651-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20933"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.07.012"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"e_1_2_5_19_1","unstructured":"Common terminology criteria for adverse events v4.0 NCI NIH DHHS. May 29 NIH publication # 09\u20107473.2009. Available from URL:http:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/CTCAE_4.03_2010\u201006\u201014_QuickReference_5x7.pdf"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1000"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020514804325"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26014"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.343"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.80"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26300"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2945"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.9190"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgn171"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21638"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06439.x"},{"key":"e_1_2_5_31_1","first-page":"721","volume-title":"Goodman and Gilman's the Pharmacological Basis of Therapeutics","author":"Brunton L","year":"2011"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083754"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27431"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70106-6"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056770"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12988","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.12988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.12988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:41:03Z","timestamp":1696236063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.12988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,12]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/jgh.12988"],"URL":"https:\/\/doi.org\/10.1111\/jgh.12988","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,12]]},"assertion":[{"value":"2015-04-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}