{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:30:47Z","timestamp":1790397047232,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Liver Cirrhosis Clinical Research Center","award":["HI10C2020"],"award-info":[{"award-number":["HI10C2020"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"Abstract<\/jats:title>Background and Aim<\/jats:title>Non\u2010alcoholic fatty liver disease (NAFLD<\/jats:styled-content>) has a close relationship with coronary atherosclerosis. We investigated the association between coronary atherosclerosis and liver fibrosis, represented as coronary artery calcification (CAC<\/jats:styled-content>) score, and live stiffness (LS<\/jats:styled-content>) value assessed using transient elastography (TE<\/jats:styled-content>), respectively, in patients with NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Between J<\/jats:styled-content>anuary 2013 and M<\/jats:styled-content>arch 2014, a total of 285 asymptomatic subjects without chronic liver and ischemic heart diseases who underwent comprehensive medical health check\u2010up were recruited. NAFLD<\/jats:styled-content> was defined as controlled attenuation parameter (CAP<\/jats:styled-content>)\u2009\u2265\u2009250 dB\/m on TE<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>The median age of the study population (men 161 and women 124) was 56 (interquartile [IQR<\/jats:styled-content>], 50\u201363) years. Of these, 142 (49.8%) subjects had NAFLD<\/jats:styled-content>. Among subjects with NAFLD<\/jats:styled-content>, CAC<\/jats:styled-content> score was independently correlated with the male gender (\u03b2\u2009=\u20090.230; P<\/jats:italic>\u2009=\u20090.010), elevated erythrocyte sedimentation rate (\u03b2\u2009=\u20090.220; P<\/jats:italic>\u2009=\u20090.019), reduced estimated glomerular filtration rate (\u03b2=\u22120.220; P<\/jats:italic>\u2009=\u20090.004), increased left ventricular mass index (\u03b2\u2009=\u20090.226; P<\/jats:italic>\u2009=\u20090.027), and higher LS<\/jats:styled-content> values (\u03b2\u2009=\u20090.274; P<\/jats:italic>\u2009<\u20090.001). In addition, alanine aminotransferase level (\u03b2\u2009=\u20090.214, P<\/jats:italic>\u2009=\u20090.012) and CAC<\/jats:styled-content> score (\u03b2\u2009=\u20090.311; P<\/jats:italic>\u2009=\u20090.001) are the only independent factors associated with LS<\/jats:styled-content> values in subjects with NAFLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Higher CAC<\/jats:styled-content> score was independently correlated with LS<\/jats:styled-content> values in subjects with NAFLD<\/jats:styled-content>. However, it should be further investigated whether TE<\/jats:styled-content> can be incorporated into a screening tool to identify the high\u2010risk population for coronary artery disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.12992","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T09:35:42Z","timestamp":1431596142000},"page":"1536-1542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hepatic fibrosis assessed using transient elastography independently associated with coronary artery calcification"],"prefix":"10.1111","volume":"30","author":[{"given":"Seng Chan","family":"You","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Severance Executive Healthcare 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