{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:24:24Z","timestamp":1740126264431,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["24390086"],"award-info":[{"award-number":["24390086"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>O<\/jats:italic><\/jats:styled-content>\u2010glycans exhibiting terminal \u03b11,4\u2010linked <jats:styled-content style=\"fixed-case\"><jats:italic>N<\/jats:italic><\/jats:styled-content>\u2010acetylglucosamine (\u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c) are attached to <jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content> in gastric gland mucins and serve as a tumor suppressor for gastric adenocarcinoma. Gastric atrophy is associated with risk for gastric cancer. However, the significance of \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c expression in pyloric glands of chronic atrophic gastritis remains unknown. Here, we asked whether reduced \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c expression in chronic atrophic gastritis is associated with risk for gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We quantitatively analyzed expression of \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c relative to <jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content> in pyloric glands by immunohistochemistry in 67 patients with normal mucosa, 70 with chronic atrophic gastritis, 68 with intramucosal differentiated\u2010type adenocarcinoma, and 11 with intramucosal undifferentiated\u2010type adenocarcinoma. We also compared the <jats:styled-content style=\"fixed-case\"><jats:roman>Ki\u201067<\/jats:roman><\/jats:styled-content> labeling index in gastric epithelial cells between chronic atrophic gastritis and normal gastric mucosa with respect to \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In normal pyloric mucosa, \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c was co\u2010expressed with <jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content>. By contrast, in chronic atrophic gastritis, pyloric gland \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c expression was significantly reduced relative to <jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content>. In intramucosal gastric cancer, \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c expression in pyloric glands found just beneath differentiated\u2010type adenocarcinoma was also reduced relative to <jats:styled-content style=\"fixed-case\">MUC6<\/jats:styled-content>. However, pyloric glands present beneath undifferentiated\u2010type adenocarcinoma exhibited no \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c decrease. The <jats:styled-content style=\"fixed-case\"><jats:roman>Ki\u201067<\/jats:roman><\/jats:styled-content> labeling index in chronic atrophic gastritis showing \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c reduction was significantly increased relative to that in normal gastric mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Because \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c prevents the gastric cancer development, reduced \u03b1<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>lc<jats:styled-content style=\"fixed-case\">NA<\/jats:styled-content>c expression in chronic atrophic gastritis is a possible risk factor for differentiated\u2010type adenocarcinoma of the stomach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13000","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T10:33:20Z","timestamp":1431513200000},"page":"1478-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reduced gland mucin\u2010specific <scp><i>O<\/i><\/scp>\u2010glycan in gastric atrophy: A possible risk factor for differentiated\u2010type adenocarcinoma of the stomach"],"prefix":"10.1111","volume":"30","author":[{"given":"Shigenori","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Shinshu University Graduate School of Medicine  Matsumoto Japan"},{"name":"Department of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuma","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Shinshu University Graduate School of Medicine  Matsumoto Japan"},{"name":"Department of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Shinshu University Graduate School of Medicine  Matsumoto Japan"},{"name":"Department of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"},{"name":"Department of Gastroenterology Iiyama Red Cross Hospital  Iiyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Shinshu University Graduate School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1273","article-title":"Unidentified curved bacilli on gastric epithelium in active chronic gastritis","author":"Warren JR","year":"1983","journal-title":"Lancet"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853899509002470"},{"key":"e_1_2_7_4_1","first-page":"192","article-title":"Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH","volume":"82","author":"Morris A","year":"1987","journal-title":"Am. 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