{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:25Z","timestamp":1787015545929,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Objective evaluation of intestinal mucosal damage due to anticancer drugs is generally difficult. Serum diamine oxidase (\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      ) activity is reported to reflect the integrity and maturity of the small intestinal mucosa. Therefore, we investigated whether serum\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity is an indicator of gastrointestinal toxicity or nutritional status in patients receiving chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We prospectively enrolled 20 patients with unresectable metastatic gastric cancer who received oral\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      \u20101 (80\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) on days 1\u201314, and intravenous cisplatin (60\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and docetaxel (50\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) on day 8 every 3 weeks. Serum\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity was measured by colorimetry. Gastrointestinal toxicity was evaluated by\n                      <jats:styled-content style=\"fixed-case\">Co<\/jats:styled-content>\n                      mmon\n                      <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                      oxicity\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      riteria for\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      dverse\n                      <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\n                      vents version 4.0. Endoscopic examination and biopsy of duodenal mucosa assessed mucosal damage. Malnutrition was evaluated by measuring serum total protein and albumin levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Serum\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity decreased step\u2010by\u2010step significantly during anticancer drug treatment and recovered after drug holidays. In all 14 patients who experienced diarrhea, serum\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity significantly decreased prior to diarrhea onset. Percent decrease in\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity was significantly correlated with severity of diarrhea. Significant correlation was observed between percent decrease in\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity and percent decrease in duodenal villus height or surface area from baseline. There were also significant correlations between percent decrease in serum\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity at day 14 and percent decrease in serum total protein or albumin levels at day 21 from baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Serum\n                      <jats:styled-content style=\"fixed-case\">DAO<\/jats:styled-content>\n                      activity sensitively indicates gastrointestinal damage prior to symptom onset and can be a useful predictor of intestinal mucosal damage and nutritional status in patients receiving chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.13004","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T06:33:49Z","timestamp":1431498829000},"page":"1582-1590","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugs"],"prefix":"10.1111","volume":"30","author":[{"given":"Jinsei","family":"Miyoshi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Oncology Institute of Health Biosciences University of Tokushima Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Oncology Institute of Health Biosciences University of Tokushima Graduate School  Tokushima 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