{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:23:29Z","timestamp":1768926209063,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To examine the relationship between hyponatremia and portal hemodynamics and their effect on the prognosis of cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Portal hemodynamic parameters measured by <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>oppler ultrasound and serum sodium concentrations were examined in 153 cirrhosis patients (mean age 62.2\u2009\u00b1\u200912.0 years; median observation period, 34.1\u2009m).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Study participants included 16 patients with hyponatremia (<jats:styled-content style=\"fixed-case\"><jats:roman>Na<\/jats:roman><\/jats:styled-content>\u2009&lt;\u2009135\u2009mEq\/L), who showed a significantly greater frequency of possessing a splenorenal shunt (<jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>; <jats:italic>P<\/jats:italic>\u2009=\u20090.0068), and 137 patients without hyponatremia. Serum sodium concentrations were significantly lower in patients with <jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content> than in those without (<jats:italic>P<\/jats:italic>\u2009=\u20090.0193). An increased prothrombin time\u2010international normalized ratio was a significant predictive factor for developing hyponatremia a year later (8\/96; Hazard ratio 14.415; <jats:italic>P<\/jats:italic>\u2009=\u20090.028). The cumulative survival rate was significantly lower in patients with hyponatremia (46.7% at 1 and 3 years) than in those without (91.8% at 1 year, 76.8% at 3 years; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The cumulative survival rate was significantly lower in patients who had developed hyponatremia after 1 year (100% at 1 year, 62.5% at 3 years) than those who had not (100% at 1 year, 89.0% at 3 years; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The cumulative survival rate was significantly worse in patients with both hyponatremia and <jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content> (20% at 1 year).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a close linkage between the serum sodium concentration and portal hemodynamic abnormality, presence of <jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>, and their interaction may negatively influence the prognoses in cirrhosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13006","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T10:34:11Z","timestamp":1431513251000},"page":"1635-1642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship and interaction between serum sodium concentration and portal hemodynamics in patients with cirrhosis"],"prefix":"10.1111","volume":"30","author":[{"given":"Hitoshi","family":"Maruyama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Kiyono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Sekimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Okugawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yokosuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60121-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22418"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801209"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.033"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280337"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005253422107"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/got037"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.007"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1990.tb01425.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2010.02326.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_5_13_1","volume-title":"The General Rules for Study of Portal Hypertension","author":"The Japan Society for Portal Hypertension","year":"2013"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31250"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099580"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26359"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5852"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2013.11.001"},{"key":"e_1_2_5_19_1","first-page":"450","article-title":"Clinical and portal hemodynamic features in cirrhotic patients having a large spontaneous splenorenal and\/or gastrorenal shunt","volume":"81","author":"Ohnishi K","year":"1986","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-89"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22172"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.02.010"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.31"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02830.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12721"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.06.004"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3283407158"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.05.005"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.05.004"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2276-3"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080451"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.09.026"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21412"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:40:15Z","timestamp":1696236015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,12]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/jgh.13006"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13006","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,12]]},"assertion":[{"value":"2015-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}