{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:16Z","timestamp":1792787056426,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T00:00:00Z","timestamp":1444608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chongqing Municipal Health Bureau","award":["2013-2-128"],"award-info":[{"award-number":["2013-2-128"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Transarterial chemoembolization (\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      ) is used for treating unresectable hepatocellular carcinoma (\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      ), but its efficacy still needs to be improved. Recombinant adenovirus\n                      <jats:italic>p<\/jats:italic>\n                      53 (r\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      d\u2010\n                      <jats:italic>p<\/jats:italic>\n                      53) injection is a gene therapeutic agent that could improve the prognosis of\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      patients. This study aimed to evaluate the efficacy and safety of r\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      d\u2010\n                      <jats:italic>p<\/jats:italic>\n                      53\u2010based\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      for treating unresectable\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Prospective analysis of patients who received r\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      d\u2010\n                      <jats:italic>p<\/jats:italic>\n                      53\u2010based\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      alone in\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      hongqing\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ancer\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      nstitute from\n                      <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>\n                      anuary 1, 2011 to\n                      <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>\n                      ecember 31, 2012. The primary endpoint is overall survival. The secondary endpoints were progression\u2010free survival, response rate, and safety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred two patients were enrolled in this study. Forty\u2010nine patients received the r\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      d\u2010\n                      <jats:italic>p<\/jats:italic>\n                      53\u2010based\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      , and 53 patients received\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      alone. The r\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      d\u2010\n                      <jats:italic>p<\/jats:italic>\n                      53\u2010based\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      treatment strategy improved the overall survival (hazard ratio: 0.58, 95% confidence interval: 0.35\u20130.96,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.035), progression\u2010free survival (hazard ratio: 0.60, 95% confidence interval: 0.37\u20130.97,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.037), response rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.047) compared with\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      monotherapy. The r\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      d\u2010\n                      <jats:italic>p<\/jats:italic>\n                      53\u2010based\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      treatment group caused more occurrences of fever than with\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      alone (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). However, symptomatic treatment may solve this problem.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      r\n                      <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>\n                      d\u2010\n                      <jats:italic>p<\/jats:italic>\n                      53\u2010based\n                      <jats:styled-content style=\"fixed-case\">TACE<\/jats:styled-content>\n                      treatment strategy is effective and safe for treating unresectable\n                      <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>\n                      . Large\u2010scale randomized clinical trials are needed to verify these results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.13009","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T06:34:34Z","timestamp":1431498874000},"page":"1651-1656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>p<\/i>\n                    53 gene therapy\u2010based transarterial chemoembolization for unresectable hepatocellular carcinoma: A prospective cohort study"],"prefix":"10.1111","volume":"30","author":[{"given":"Ai","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Chongqing Cancer Institute  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Chongqing Cancer Institute  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqian","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Chongqing Cancer Institute  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Chongqing Cancer Institute  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingdong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Chongqing Cancer Institute  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.091"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200107000-00011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50047"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-006-0062-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.09.032"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S31440"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.12.011"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068574"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32832a2df9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i16.2143"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0701-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9165-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850802133386"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.12.001"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27290"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0313"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.05.007"},{"key":"e_1_2_6_22_1","first-page":"430","article-title":"Radiofrequency ablation alone versus radiofrequency ablation combined with chemoembolization in unresectable hepatocellular carcinoma","volume":"95","author":"Siriapisith T","year":"2012","journal-title":"J. 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