{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:18:39Z","timestamp":1781921919694,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:00:00Z","timestamp":1448323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Key Medical Research Subjects in Hebei Province [2012]","award":["2056"],"award-info":[{"award-number":["2056"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>This study aimed to estimate the time to precursor progression and to identify significant predicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>One hundred thirty\u2010three precursor and 311 normal cases detected in a population\u2010based screening were surveyed for 5.5 years. Precursor progression was defined as worsening of dysplasia or development of a new precursor. Time to precursor progression was estimated by the Kaplan\u2010Meier method. Significant predicators were estimated by Cox proportional regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Of the 133 precursor cases, 33.08% (44\/133) progressed or recurred, 30.08% (40\/133) persisted, and 36.84% (49\/133) regressed; of the 311 normal subjects, 13.50% (42\/311) developed a precursor. Progression occurred significantly earlier and more frequently with ncreasing histology: with mind dysplasia (mD), 7.8% progressed by 1\u2009year and 23.3% progressed by 5\u2009year; with moderate dysplasia (MD), 18% progressed by 1\u2009year and 70% progressed by 5\u2009years; and with severe dysplasia, 50% progressed by 1\u2009year and 100% progressed by 5\u2009years. The difference between any two groups was significant. In addition, the marginal Lugol\u2010stained mucosa at endoscopic mucosal resection had a progressing risk similar to that of MD, and basal cell hyperplasia was similar to that of mD. Significant predicators for precursor progression included male sex (hazard ratio and 95% CI: 2.74 (1.63\u20134.60)), age over 50\u2009years (2.31 (1.33\u20134.02)), family history of upper gastrointestinal cancer (UGIC) (1.56 (1.00\u20132.45)), multifocal dysplasia (5.11 (3.01\u20138.68)), and baseline histology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Sex, age, family history of UGIC, multifocal dysplasia, and baseline histology are significant independent predicators for precursor progression. Patients after endoscopic mucosal resection should be continuously surveyed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13040","type":"journal-article","created":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T20:03:12Z","timestamp":1437076992000},"page":"1720-1725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A 5.5\u2010year surveillance of esophageal and gastric cardia precursors after a population\u2010based screening in China"],"prefix":"10.1111","volume":"30","author":[{"given":"Denggui","family":"Wen","sequence":"first","affiliation":[{"name":"Cancer Institute the Fourth Hospital of Hebei Medical University  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endoscope the Fourth Hospital of Hebei Medical University  Shijiazhuang 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