{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T08:14:31Z","timestamp":1696580071698},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning","award":["NRF-2014R1A1A1008585","HI10C2020"],"award-info":[{"award-number":["NRF-2014R1A1A1008585","HI10C2020"]}]},{"name":"Liver Cirrhosis Clinical Research Center"},{"name":"Korea Healthcare technology R & D project, Ministry of Health and Welfare, Republic of Korea"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>We investigated the long\u2010term efficacy of adefovir add\u2010on lamivudine rescue therapy in lamivudine\u2010resistant chronic hepatitis B and the optimal cutoff hepatitis B virus (HBV) DNA level that predicts complete virological response (CVR) among patients without CVR after 1\u2009year of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We reviewed 167 lamivudine\u2010resistant chronic hepatitis B patients who received adefovir add\u2010on rescue therapy for up to 5\u2009years. Multivariate analysis, area under the receiver operating characteristic curves, and Youden index were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Median age was 47.0\u2009years; 112 patients were male. Median baseline HBV DNA level was 6.6\u2009log<jats:sub>10<\/jats:sub>\u2009IU\/mL; hepatitis B e antigen was positive in 130 (77.4%) patients. Five\u2010year CVR, alanine aminotransferase normalization, hepatitis B e antigen seroconversion, and adefovir resistance rates were 86.9%, 92.5%, 16.7%, and 6.0%, respectively. One\u2010year HBV DNA level independently associated with CVR. Optimal cutoff HBV DNA level to predict CVR among patients who failed to achieve CVR at 1\u2009year was 800\u2009IU\/mL (area under receiver operating characteristic curve 0.752; sensitivity 49.3%, specificity 93.5%). During the 5\u2010year treatment, 92.1% of patients with favorable response (HBV DNA\u2009&lt;\u2009800\u2009IU\/mL at 1\u2009year) achieved CVR; 45.6% achieved CVR among suboptimal responders (HBV DNA\u2009\u2265\u2009800\u2009IU\/mL at 1\u2009year) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Complete virological response or HBV DNA level\u2009&lt;\u2009800\u2009IU\/mL after 1\u2009year adefovir add\u2010on lamivudine rescue therapy can favorably predict CVR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13046","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T23:23:12Z","timestamp":1437607392000},"page":"241-247","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of adefovir add\u2010on lamivudine rescue therapy of up to 5\u2009years in patients with lamivudine\u2010resistant chronic hepatitis B"],"prefix":"10.1111","volume":"31","author":[{"given":"Sung Bae","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Up","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"},{"name":"Institute of Gastroenterology Yonsei University College of Medicine  Seoul Korea"},{"name":"Liver Cirrhosis Clinical Research Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.02.010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2012.18.2.109"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2893.2003.00487.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.562"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200205303462202"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v3.i12.292"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807093390201"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.09.033"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.10.051"},{"key":"e_1_2_6_11_1","first-page":"777","article-title":"Update on rescue therapies in patients with lamivudine\u2010resistant chronic hepatitis B","volume":"7","author":"Chao DC","year":"2013","journal-title":"Drug Des. Devel. Ther."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021812"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020681"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-163"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.08.079"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP2335"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2012.01038.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.22025"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0864-4"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20723"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000348853"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24121"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23044"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24361"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21189"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.12.018"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23371"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.09.020"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0779-0"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21253"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/135965350701200309","article-title":"In vitro susceptibility of adefovir\u2010associated hepatitis B virus polymerase mutations to other antiviral agents","volume":"12","author":"Qi X","year":"2007","journal-title":"Antivir. Ther."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23246"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.223206"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2005.20.5.816"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096313"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T19:30:56Z","timestamp":1696275056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jgh.13046"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13046","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,30]]},"assertion":[{"value":"2015-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}