{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:30:19Z","timestamp":1792798219826,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Seoul Metropolitan Government - Seoul National University (SMG-SNU) Boramae Medical Center","award":["03-2014-7"],"award-info":[{"award-number":["03-2014-7"]}],"id":[{"id":"https:\/\/ror.org\/04h9pn542","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Alcoholic liver diseases often evolve to acute\u2010on\u2010chronic liver failure (ACLF), which increases the risk of (multi\u2010)organ failure and death. We investigated the development and characteristics of alcohol\u2010related ACLF and evaluated prognostic scores for prediction of mortality in Asian patients with active alcoholism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 205 patients who were hospitalized with severe alcoholic liver disease were included in this retrospective cohort study, after excluding those with serious cardiovascular diseases, malignancy, or co\u2010existing viral hepatitis. The Chronic Liver Failure (CLIF) Consortium Organ Failure score was used in the diagnosis and grading of ACLF, and the CLIF Consortium ACLF score (CLIF\u2010C ACLFs) was used to predict mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with ACLF had higher Maddrey discriminant function, model for end\u2010stage liver disease (MELD), and MELD\u2010sodium scores than those without ACLF. Infections were more frequently documented in patients with ACLF (33.3%\n                      <jats:italic>vs<\/jats:italic>\n                      53.0%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.004). Predictive factors for ACLF development were systemic inflammatory response syndrome (odds ratio [OR], 2.239;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), serum sodium level (OR, 0.939;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.029), and neutrophil count (OR, 1.000;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.021). For prediction of mortality at predefined time points (28\u2010day and 90\u2010day) in patients with ACLF, areas under the receiver\u2010operating characteristic were significantly greater for the CLIF\u2010C ACLFs than for Child\u2013Pugh, MELD, and MELD\u2010sodium scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Infection and systemic inflammatory response syndrome play an important role in the development of alcohol\u2010related ACLF in Asian patients with active alcoholism. The CLIF\u2010C ACLFs may be more useful for predicting mortality in ACLF cases than liver\u2010specific scoring systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.13084","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T01:45:32Z","timestamp":1439257532000},"page":"427-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Characterization of acute\u2010on\u2010chronic liver failure and prediction of mortality in Asian patients with active alcoholism"],"prefix":"10.1111","volume":"31","author":[{"given":"Hwi Young","family":"Kim","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine Seoul Metropolitan Government \u2010 Seoul National University Boramae Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongkeun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeki","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Jun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University Hospital  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohee","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Seoul Metropolitan Government \u2010 Seoul National University Boramae Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul Metropolitan Government \u2010 Seoul National University Boramae Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong Gwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul Metropolitan Government \u2010 Seoul National University Boramae Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kook Lae","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul Metropolitan Government \u2010 Seoul National University Boramae Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Seoul Metropolitan Government \u2010 Seoul National University Boramae Medical Center  Seoul 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