{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:56:27Z","timestamp":1790517387825,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T00:00:00Z","timestamp":1456444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dongguk University Research Fund 2010"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between visceral adiposity and the incidence of functional dyspepsia (FD) has not yet been studied. The purpose of the present study is to evaluate the association between visceral adiposity and the risk of FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a case\u2013control study that compares the abdominal adipose tissue area between subjects with FD and control subjects without FD, who underwent abdomen computerized tomography (CT) for health examinations in a tertiary center. Retrospectively, a telephone survey was conducted to diagnose FD using the Rome III criteria. We measured various indices of obesity including body mass index (BMI), waist circumference (WC), visceral adipose tissue (VAT) area, subcutaneous adipose tissue (SAT) area and the VAT\/SAT ratio in order to evaluate the association between FD and abdominal adiposity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>A total of 363 subjects were included in the present study. FD was diagnosed in 90 subjects (24.8%). In the univariate analysis, WC, VAT area, TAT area, VAT\/SAT ratio, and the presence of erosive esophagitis were significantly higher in the FD group than in the non\u2010FD group. In the multivariate analysis, a higher VAT area (odds ratio (OR), 3.76; 95% confidence interval (CI), 1.24\u201311.40; highest quartile <jats:italic>vs<\/jats:italic> lowest quartile, <jats:italic>p\u2009=<\/jats:italic>\u20090.019) and VAT\/SAT ratio (OR, 2.35; 95% CI, 1.27\u20134.32; highest quartile <jats:italic>vs<\/jats:italic> lowest quartile, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) were independently associated with a risk of FD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Inferences<\/jats:title><jats:p>Visceral adiposity as measured by the VAT area and VAT\/SAT ratio is associated with an increased risk of FD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13146","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T23:47:29Z","timestamp":1440719249000},"page":"567-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Visceral adiposity is associated with an increased risk of functional dyspepsia"],"prefix":"10.1111","volume":"31","author":[{"given":"Jae Gu","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, College of Medicine  Goyang Republic of Korea"},{"name":"Department of Internal Medicine Incheon Sarang Hospital  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Nam","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, College of Medicine  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Geun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, College of Medicine  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, College of Medicine  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Gun","family":"Kwack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, College of Medicine  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, College of Medicine  Goyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoun Woo","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dongguk University Ilsan Hospital, College of Medicine  Goyang Republic of 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