{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:21:44Z","timestamp":1790896904461,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007299","name":"Harvard Catalyst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims:<\/jats:title><jats:p>Multiple European studies report increased prevalence of selective immunoglobulin A deficiency (SIgAD) and partial immunoglobulin A deficiency (PIgAD) in patients with celiac disease (CD). However; prospective data representing North American adults are lacking. While SIgAD precludes the use of IgA\u2010tissue\u2010transglutaminase antibody (IgA\u2010tTG), the effect of PIgAD on IgA\u2010tTG sensitivity is not well documented. We aim to determine the prevalence and impact of IgA deficiency on CD presentation and diagnosis in North American adult patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We reviewed 1000 consecutive patients undergoing IgA\u2010tTG testing and 243 healthy controls. Eligible sera were tested for IgA\u2010tTG, serum immunoglobulins, and IgA\/IgG\u2010deamidated gliadin peptide (IgA\/IgG\u2010DGP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Prevalence of SIgAD was marginally higher in patients with CD (1.9%) compared with healthy controls (0.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.24) and patients without CD (0.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.173). Prevalence of PIGAD was similar in patients with CD (4.8%) compared with healthy controls (5.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.57) and patients without CD (7.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.22). One (16.7%) of 6 patients with CD with SIgAD and all 15 (100%) with PIGAD tested IgA\u2010tTG positive prior to gluten\u2010free diet initiation. Patients with CD with SIGAD showed lower frequency of gastrointestinal symptoms (33% <jats:italic>vs<\/jats:italic> 82%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01) and more co\u2010morbid autoimmune disease (67% <jats:italic>vs<\/jats:italic> 23%, <jats:italic>P<\/jats:italic>\u2009=\u20090.03) when compared with patients with CD with normal IgA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The prevalence of SIgAD in North American patients with CD is comparable with European data but not significantly different than control populations. Patients with CD with SIgAD exhibit decreased IgA\u2010tTG sensitivity and lack of gastrointestinal symptoms. PIgAD is common in patients with gastrointestinal disorders but does not alter CD presentation or IgA\u2010tTG sensitivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13176","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T06:00:51Z","timestamp":1443420051000},"page":"133-137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Immunoglobulin A deficiency in celiac disease in the United States"],"prefix":"10.1111","volume":"31","author":[{"given":"Kumar","family":"Pallav","sequence":"first","affiliation":[{"name":"Celiac Center Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"},{"name":"Division of Digestive Diseases University of Mississippi Medical Center  Jackson Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Celiac Center Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Leffler","sequence":"additional","affiliation":[{"name":"Celiac Center Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toufic","family":"Kabbani","sequence":"additional","affiliation":[{"name":"Celiac Center Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciaran P.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Celiac Center Beth Israel Deaconess Medical Center and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.1999.4799"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.08.053"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012241117984"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-009-9357-x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199709000-00004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31824b2277"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.3.362"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023247117133"},{"key":"e_1_2_9_10_1","first-page":"88","article-title":"Epidemiological study of selective IgA deficiency among 6 nationalities in China","volume":"72","author":"Feng L","year":"1992","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1986.tb04851.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1128\/CDLI.7.2.192-196.2000","article-title":"Immunoglobulin A (IgA) deficiency and alternative celiac disease\u2010associated antibodies in sera submitted to a reference laboratory for endomysial IgA testing","volume":"7","author":"Prince HE","year":"2000","journal-title":"Clin. 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