{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:31:25Z","timestamp":1790627485952,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Colorectal cancer (CRC) screening is based on colonoscopy or fecal occult blood tests, but is imperfect and costly. The Asia Pacific Colorectal Screening Score (APCS) is derived from age, sex, family history of CRC, and smoking history and has been validated in Asian populations. Validation in a Western population is, however, yet to be tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a teaching hospital, patients underwent colonoscopy for standard indications and screening over 18\u2009months. Data was collected on age, sex, family history of CRC, smoking, weight, ethnicity, and symptoms. Evaluation of the APCS to predict colonoscopy findings (polyps, adenoma, high risk adenoma, and CRC) was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 645 patients were prospectively recruited (46.7% male, median age 57\u2009years); 17.8% were average risk (AR), 50.9% were moderate risk (MR), and 31.3% high risk (HR) on APCS. High risk adenomas (AA) were seen in 14.9% of the HR, 5.2% MR, and 0.9% LR patients, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001. Comparing HR and MR to AR patients demonstrated significantly elevated relative risk (RR) for AA: 17.1 (95% confidence interval [CI] 2.4\u2013123; <jats:italic>P<\/jats:italic>\u2009=\u20090.0001), and adenoma 6.0 (0.80\u201344.3; <jats:italic>P<\/jats:italic>\u2009=\u20090.044). Comparing HR to MR groups for AA, the RR was 2.87 (1.62\u20135.06; <jats:italic>P<\/jats:italic>\u2009=\u20090.0001). Symptoms did not predict findings (odds ratio [OR]: 1.06 [0.75\u20131.48]; <jats:italic>P<\/jats:italic>\u2009=\u20090.75). Body mass index (BMI) &lt;20\u2009kg\/m<jats:sup>2<\/jats:sup> was protective against colonic polyps (OR: 0.28, 95%CI: 0.11\u20130.74; <jats:italic>P<\/jats:italic>\u2009=\u20090.010), adenoma (0.08, 0.01\u20130.62; <jats:italic>P<\/jats:italic>\u2009=\u20090.015), and AA (perfect prediction, OR 2.35\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>APCS predicts colonic findings in a Western population, to a greater extent than in Asians, independent to symptoms. Low body weight carries a strong protective effect against colonic neoplasia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13196","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T18:48:47Z","timestamp":1445366927000},"page":"370-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Validation of the Asia Pacific Colorectal Screening (APCS) score in a Western population: An alternative screening tool"],"prefix":"10.1111","volume":"31","author":[{"given":"Crispin","family":"Corte","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Concord Hospital"},{"name":"Faculty of Medicine UNSW  Australia"},{"name":"Faculty of Medicine University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lora","family":"Zhang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine UNSW  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Chen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine UNSW  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Westbury","sequence":"additional","affiliation":[{"name":"Faculty of Medicine UNSW  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Shaw","sequence":"additional","affiliation":[{"name":"Faculty of Medicine UNSW  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khay Guan","family":"Yeoh","sequence":"additional","affiliation":[{"name":"Department of Medicine National University of Singapore  Singapore"},{"name":"Department of Gastroenterology and Hepatology National University Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Concord Hospital"},{"name":"Faculty of Medicine UNSW  Australia"},{"name":"Faculty of Medicine University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.56.2.106"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0437"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70422-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90563-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292701"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50044"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.agast970594"},{"key":"e_1_2_6_10_1","unstructured":"Guidelines for the Prevention Early Detection and Management of Colorectal Cancer.Sydney:The Cancer Council Australia and Australian Cancer Network 2005."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.002"},{"key":"e_1_2_6_12_1","unstructured":"Improving Outcomes in Colorectal Cancers.London:National Institute for Health and Clinical Excellence 2004."},{"key":"e_1_2_6_13_1","unstructured":"Improving Colonoscopy Services in Australia.The National Bowel Cancer Screening Program Quality Working Group Ageing AGDoHa;2009."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-8-200010170-00007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2013.05.003"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-97"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-65"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04344.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.20"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-12-0014"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.221168"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i32.11394"},{"key":"e_1_2_6_23_1","article-title":"Development and validation of a risk stratification\u2010based screening model for predicting colorectal advanced neoplasia in Korea","author":"Kim DH","year":"2014","journal-title":"J. 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