{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:22:17Z","timestamp":1761740537549,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V101C-082"],"award-info":[{"award-number":["V101C-082"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Portal\u2010systemic collaterals lead to dreadful consequences in patients with cirrhosis. Angiogenesis participates in the development of liver fibrosis, hyperdynamic circulation, and portal\u2010systemic collaterals. 2\u2032\u2010Hydroxyflavanone (2\u2032\u2010HF), one of the citrus fruits flavonoids, is known to have antiangiogenesis effect without adverse response. However, the relevant effects in liver fibrosis have not been surveyed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Wistar rats received thioacetamide (TAA, 100\u2009mg\/kg tiw, i.p.) for 6\u2009weeks to induce liver fibrosis. On the 29th to 42nd day, rats randomly received 2\u2032\u2010HF (100\u2009mg\/kg, qod, i.p.) or vehicle (corn oil). On the 43rd day, after hemodynamic measurements, the followings were surveyed: (i) severity of collaterals; (ii) mesenteric angiogenesis; (iii) mesenteric proangiogenic factors protein expressions; (iv) Mesenteric vascular endothelial cells apoptosis; and (v) Mesenteric expressions of proteins regulating apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the vehicle group, 2\u2032\u2010HF did not significantly change body weight, mean arterial pressure, heart rate, and portal pressure in TAA rats. 2\u2032\u2010HF significantly alleviated the severity of collaterals, but the mesenteric phospho\u2010ERK, ERK, phospho\u2010Akt, Akt, COX1, COX2, VEGF, and VEGFR\u20102 protein expressions were not altered. The apoptotic index of 2\u2032\u2010HF group was significantly higher and the mesenteric protein expressions of pro\u2010apoptotic factors, NFkB 50, NFkB 65, Bax, phospho\u2010p53, 17\u2009kD cleaved caspase 3, and 17\u2009kD casepase 3 were up\u2010regulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>2\u2032\u2010HF does not influence the hemodynamics but alleviated the severity of collaterals in rats with liver fibrosis and early portal hypertension. This is, at least partly, attributed to enhanced apoptosis of mesenteric vascular endothelial cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13197","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T21:04:18Z","timestamp":1445029458000},"page":"1045-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["2'\u2010Hydroxyflavanone ameliorates mesenteric angiogenesis and portal\u2010systemic collaterals in rats with liver fibrosis"],"prefix":"10.1111","volume":"31","author":[{"given":"I\u2010Fang","family":"Hsin","sequence":"first","affiliation":[{"name":"Institute of Pharmacology National Yang\u2010Ming University  Taipei Taiwan"},{"name":"Faculty of Medicine National Yang\u2010Ming University School of Medicine  Taipei Taiwan"},{"name":"Endoscopy Center for Diagnosis and Treatment  Taipei 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