{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:58:31Z","timestamp":1776772711355,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Science and technology development Foundation, Nanjing Department of Health, China","award":["ZKX14017"],"award-info":[{"award-number":["ZKX14017"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Propranolol is widely used to prevent gastroesophageal variceal bleeding; however, some patients could not benefit from propranolol. This study is to evaluate the relationship between CYP2D6 and \u03b22\u2010adrenergic receptor (\u03b22\u2010AR) gene polymorphisms and the hemodynamic response to propranolol in Chinese Han patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of patients with gastroesophageal varices undergoing hepatic venous pressure gradient (HVPG) measurement before and 7\u2009days after oral propranolol administration in our department were collected. Four single nucleotide polymorphisms of CYP2D6 and \u03b22\u2010AR genes were detected. The relationship was identified by logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients were involved in the analysis. Sixty milligram propranolol twice each day was well tolerated by all the patients. The initial and secondary average of HVPG was 17.4\u2009\u00b1\u20095.8\u2009mmHg vs. 13.2\u2009\u00b1\u20094.8\u2009mmHg, respectively (<jats:italic>t<\/jats:italic>\u2009=\u20095.726, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Twenty patients responded to propranolol. The mean reduction value of HVPG was 6.6\u2009\u00b1\u20093.6\u2009mmHg (range from 3 to 19). Genotype analysis showed: 20 homozygotes for C\/C188 and 10 for heterozygous C\/T188, 8 homozygotes for G\/G4268 and 22 heterozygotes for G\/C4268, 14 homozygotes for Gly16 and 10 heterozygotes, and 6 homozygotes for Arg16, 27 homozygotes for Gln27 and 3 heterozygotes. The multivariate logistic regression analysis indicated that CYP2D6 (188C&gt;T) genotype was an independent predicting factor for HVPG response to propranolol (<jats:italic>P<\/jats:italic>\u2009=\u20090.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CYP2D6 (188C&gt;T) gene polymorphisms influence the hemodynamic response to propranolol in this population of Chinese Han patients with gastroesophageal varices. However, HVPG response cannot be completely predicted from CYP2D6 and \u03b22\u2010AR gene polymorphisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13198","type":"journal-article","created":{"date-parts":[[2015,10,21]],"date-time":"2015-10-21T20:36:39Z","timestamp":1445459799000},"page":"829-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of CYP2D6 and \u03b22\u2010adrenergic receptor gene polymorphisms on the hemodynamic response to propranolol in Chinese Han patients with cirrhosis"],"prefix":"10.1111","volume":"31","author":[{"given":"Feng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhong","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenlei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qibin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengcheng","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzheng","family":"Zhuge","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Affiliated 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