{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:16:04Z","timestamp":1761844564374},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Seoul Metropolitan Government Seoul National University (SMG-SNU) Boramae Medical Center","award":["03-2015-2"],"award-info":[{"award-number":["03-2015-2"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>Gastrointestinal bleeding (GIB) often accompanies alcoholic hepatitis (AH). The study aimed to investigate clinical characteristics of GIB in AH patients and to identify risk factors for mortality in AH patients with GIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Data from 329 patients hospitalized with AH in a single center during 1999\u20132014 were retrospectively analyzed. Patients with AH were dichotomized into GIB and non\u2010GIB groups. The GIB group was further divided into portal hypertensive bleeding (PHB) and non\u2010PHB groups. Clinical characteristics and survival outcomes were compared between the groups. Risk factors for mortality were analyzed using Cox regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Among the 329 AH patients, 132 experienced GIB at admission or during hospitalization. The most common cause of GIB was an esophageal varix. The GIB group had worse survival outcomes than the non\u2010GIB group (log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u20090.034). The PHB group had worse survival outcomes than the non\u2010PHB group (log\u2010rank test, <jats:italic>P<\/jats:italic>\u2009=\u20090.001). On multivariate analysis, alcohol consumption, ascites, encephalopathy, infection, Maddrey's discriminant function, and the model for end\u2010stage liver disease (MELD) score independently predicted mortality in the entire AH cohort. The MELD score (hazard ratio, 1.085; 95% confidence interval, 1.052\u20131.120; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and PHB (hazard ratio, 2.162; 95% confidence interval, 1.021\u20134.577; <jats:italic>P<\/jats:italic>\u2009=\u20090.044) were significant prognosticators for patients with AH and GIB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>The presence of PHB and a higher MELD score adversely affected survival in AH patients with GIB. Accordingly, prompt endoscopic examination for exploring the etiologies of GIB may alert physicians to predict the risk of death in AH patients with GIB.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13220","type":"journal-article","created":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T18:12:45Z","timestamp":1446142365000},"page":"814-821","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characterization of gastrointestinal hemorrhage and prediction of mortality in Asian patients with alcoholic hepatitis"],"prefix":"10.1111","volume":"31","author":[{"given":"Su Hwan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical Center  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byeong Gwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal 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