{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:16:49Z","timestamp":1696231009854},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean Health Technology Research and Development Project; Ministry of Health and Welfare, Republic of Korea","award":["HI13C0259"],"award-info":[{"award-number":["HI13C0259"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>There are limited data assessing whether patients who achieved virological suppression on lamivudine but remain hepatitis B \u201ce\u201d antigen\u2010positive should be switched to a more potent antiviral with a high genetic barrier to resistance or continue with lamivudine. We compared the safety and efficacy of switching with entecavir versus continuing lamivudine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>This was a Phase IV, randomized, open\u2010label, prospective study in a tertiary care setting. Seventy\u2010three chronic hepatitis B patients who achieved virological suppression on lamivudine (serum hepatitis B virus DNA\u2009&lt;\u200960\u2009International Unit (IU)\/mL) were enrolled. Entecavir or lamivudine were administered orally for up to 96\u2009weeks. Virologic and serologic responses were measured throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>A significantly higher proportion of patients in the entecavir group achieved hepatitis B virus DNA\u2009&lt;\u200960\u2009IU\/mL at Weeks 48 (100% [38\/38] vs 62.8% [22\/35]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and 96 (97.4% [37\/38] vs 57.1% [20\/35]; <jats:italic>P<\/jats:italic>&lt;0.001). A greater number of patients had virologic breakthrough (Week 96 cumulative incidence 42.9% vs 2.6%; <jats:italic>P<\/jats:italic>&lt;0.001) and genotypic lamivudine resistance (28.6% [10\/35] vs 0% [0\/38]; <jats:italic>P<\/jats:italic>&lt;0.001) in the lamivudine group. No serious adverse events or laboratory abnormalities were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Even after achieving virological suppression on lamivudine therapy, the risk of emergent lamivudine resistance increases over time. Switching to entecavir resulted in a maintained virologic response and superior serologic responses versus continued lamivudine therapy. This study supports a rationale for switching to entecavir in chronic hepatitis B patients with virological suppression on lamivudine.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13231","type":"journal-article","created":{"date-parts":[[2015,11,17]],"date-time":"2015-11-17T07:30:49Z","timestamp":1447745449000},"page":"865-871","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 96\u2010week randomized trial of switching to entecavir in patients who achieved virological suppression on lamivudine therapy"],"prefix":"10.1111","volume":"31","author":[{"given":"Sang Hoon","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Young","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heon Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yeungnam University College of Medicine  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Young","family":"Tak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University School of Medicine  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Ho","family":"Um","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Tae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyungpook National University School of Medicine  Daegu Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Hoi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and BioMedical Informatics Unit Pusan National University School of Medicine  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang\u2010Hyub","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.11.6227"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.4.457"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn243"},{"key":"e_1_2_6_5_1","first-page":"338","article-title":"Management of chronic hepatitis B in treatment\u2010naive patients","volume":"51","author":"Cheong J","year":"2008","journal-title":"Korean J. 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