{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:54Z","timestamp":1790740674867,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>In high or moderate risk populations, periodic surveillance of patients at risk of progression from gastric precursor lesions (PL) to gastric cancer (GC) is the most effective strategy for reducing the burden of GC. Incomplete type of intestinal metaplasia (IIM) may be considered as the best candidate, but it is still controversial and more research is needed. To further assess the progression of subtypes of IM as predictors of GC occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A follow\u2010up study was carried\u2010out including 649 patients, diagnosed with PL between 1995\u20132004 in 9 participating hospitals from Spain, and who repeated the biopsy during 2011\u20132013. Medical information and habits were collected through a questionnaire. Based on morphology, IM was sub\u2010classified as complete (small intestinal type, CIM) and incomplete (colonic type, IIM). Analyses were done using Cox (HR) models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At baseline, 24% of patients had atrophic gastritis, 38% CIM, 34% IIM, and 4% dysplasia. Mean follow\u2010up was 12\u2009years. 24 patients (3.7%) developed a gastric adenocarcinoma during follow\u2010up. The incidence rate of GC was 2.76 and 5.76 per 1,000 person\u2010years for those with CIM and IIM, respectively. The HR of progression to CG was 2.75 (95% CI 1.06\u20106.26) for those with IIM compared with those with CIM at baseline, after adjusting for sex, age, smoking, family history of GC and use of NSAIDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IIM is the PL with highest risk to progress to GC. Sub\u2010typing of IM is a valid procedure for the identification of high risk patients that require more intensive surveillance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgh.13249","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T09:24:45Z","timestamp":1449048285000},"page":"953-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Incomplete type of intestinal metaplasia has the highest risk to progress to gastric cancer: results of the Spanish follow\u2010up multicenter study"],"prefix":"10.1111","volume":"31","author":[{"given":"Carlos A.","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Unit of Nutrition, Environment and Cancer Institut Catal\u00e0 d'Oncolog\u00eda  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Miguel","family":"Sanz\u2010Anquela","sequence":"additional","affiliation":[{"name":"University of Alcal\u00e1 (Department of Medicine and Medical Especialties), Department of Pathology Hospital Universitario Pr\u00edncipe de Asturias  Alcal\u00e1 de Henares Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osmel","family":"Companioni","sequence":"additional","affiliation":[{"name":"Unit of Nutrition, Environment and Cancer Institut Catal\u00e0 d'Oncolog\u00eda  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Bonet","sequence":"additional","affiliation":[{"name":"Unit of Nutrition, Environment and Cancer Institut Catal\u00e0 d'Oncolog\u00eda  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Berdasco","sequence":"additional","affiliation":[{"name":"Cancer Epigenetics and Biology Program IDIBELL  Barcelona"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario de la Princesa, IIS\u2010IP, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de la Princesa, IIS\u2010IP, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa Dolores","family":"Mart\u00edn\u2010Arranz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario La Paz  Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Rey","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Poves","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Pr\u00edncipe de Asturias  Alcal\u00e1 de Henares"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario Pr\u00edncipe de Asturias  Alcal\u00e1 de Henares"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Barrio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa \u00c1ngeles","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Cuatrecasas","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednic de Barcelona IDIBAPS and CIBEREHD, and Universitat de Barcelona  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Elizalde","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Cl\u00ednic de Barcelona, IDIBAPS and CIBEREHD  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[{"name":"Department of Pathology, and Department of Gastroenterology. Hospital Donostia\/Instituto Biodonostia Universidad del Pa\u00eds Vasco (UPV\/EHU). CIBEREHD  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddi","family":"Garmendia","sequence":"additional","affiliation":[{"name":"Department of Pathology, and Department of Gastroenterology. Hospital Donostia\/Instituto Biodonostia Universidad del Pa\u00eds Vasco (UPV\/EHU). CIBEREHD  San Sebasti\u00e1n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Ferr\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Cl\u00ednico Universitario Lozano Blesa, Zaragoza, and CIBEREHD  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Andreu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital de Viladecans  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa Jose","family":"Paules","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Lario","sequence":"additional","affiliation":[{"name":"Departament of Medicine, Digestive Diseases Service Institut Universitari Parc Taul\u00ed, Sabadell, and CIBEREHD  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00aa Jose","family":"Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Departament of Medicine, Digestive Diseases Service Institut Universitari Parc Taul\u00ed, Sabadell, and CIBEREHD  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2090-3445","authenticated-orcid":false,"given":"Javier P.","family":"Gisbert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Hospital Universitario de la Princesa, IIS\u2010IP, and Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD)  Madrid"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg754"},{"key":"e_1_2_9_4_1","first-page":"S37","article-title":"Helicobacter pylori and gastric carcinogenesis","volume":"19","author":"Correa P","year":"1995","journal-title":"Am. 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