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The aim of the present study was to investigate the effect of exogenous H<jats:sub>2<\/jats:sub>S on gastric acid secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Wistar rats were randomly divided into physiological saline (PS) group, sodium hydrosulfide (NaHS; 50, 100, and 150\u2009\u00b5mol\/kg body weight) group, glibenclamide\u2009+\u2009NaHS group, and SQ22536\u2009+\u2009NaHS group. PH of gastric juice before injection and after injection were determined by a PH meter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that NaHS, an exogenous H<jats:sub>2<\/jats:sub>S donor, injected into the enterocoelia significantly reduced the PH of gastric juice, the same volume of PS administered similarly did not change PH of gastric juice, the promotional effect of NaHS on gastric acid secretion could be abolished by glibenclamide, an ATP\u2010sensitive potassium channel K(ATP) blocker SQ22536, an inhibitor of adenyl cyclase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The data from these experiments suggest that exogenous H<jats:sub>2<\/jats:sub>S promoted gastric acid secretion, which may occur via K(ATP) channels and activate AC\u2010cAMP pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13269","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T07:47:05Z","timestamp":1450424825000},"page":"1280-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of exogenous hydrogen sulfide on gastric acid secretion"],"prefix":"10.1111","volume":"31","author":[{"given":"Hongzhao","family":"Sun","sequence":"first","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiyan","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuning","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Life Science Qi Lu Normal University  Jinan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00207.2006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2008.2282"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2010.05.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31816857bb"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.133538"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0407237"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.04.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6878"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.05.016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.07.060"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.109.152801"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.07.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.10.017"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803413962"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032013000200027"},{"key":"e_1_2_6_17_1","first-page":"221","article-title":"Ethical considerations in relation to pain in animal experimentation","volume":"128","author":"Zimmermann M","year":"1986","journal-title":"Acta Physiol. 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