{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:18:19Z","timestamp":1785395899374,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>Non\u2010alcoholic steatohepatitis (NASH) is one of the most common causes of chronic liver disease and is considered to be a causative factor of cryptogenic cirrhosis and hepatocellular carcinoma. The aim of this work was to investigate whether treatment with geraniol (a monoterpene) attenuated NASH induced by methionine\u2010choline\u2010deficient (MCD) diet in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Rats were fed with MCD diet to induce NASH and treated with geraniol (200\u2009mg\/kg\/day) for 10\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Treatment with geraniol reduced histological scores, fibrosis, and apoptosis in livers, lowered activities of alanine aminotransferase and aspartate aminotransferase in serum, and attenuated hepatic fat accumulation in rats fed with MCD diet. Treatment with geraniol preserved hepatic mitochondrial function, evidenced by reduced mitochondrial reactive oxygen species formation, enhanced adenosine triphosphate formation and membrane integrity, restored mitochondrial electron transport chain enzyme activity, and increased mitochondrial DNA content in rats fed with MCD diet. Treatment with geraniol reduced uncoupling protein 2 protein expression, and enhanced protein expression of prohibitin, mRNA expression of peroxisome proliferator\u2010activated receptor<jats:italic>\u03b1<\/jats:italic>, and activity of mitochondrial carnitine palmitoyl transferase\u2010I in livers of rats fed with MCD diet. Treatment with geraniol abated oxidative stress, evidenced by reduced malondialdehyde and 3\u2010nitrotyrosine formation, enhanced activity of glutathione S\u2010epoxide transferase, and down\u2010regulated expression of inducible nitric oxide synthase and cytochrome P450 2E1 in livers of rats fed with MCD diet. Treatment with geraniol reduced myeloperoxidase activity and protein expression of tumor necrosis factor alpha and IL\u20106 in livers of rats fed with MCD diet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Treatment with geraniol attenuated MCD\u2010induced NASH in rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13272","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T04:04:40Z","timestamp":1450843480000},"page":"1357-1365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Treatment with geraniol ameliorates methionine\u2010choline\u2010deficient diet\u2010induced non\u2010alcoholic steatohepatitis in rats"],"prefix":"10.1111","volume":"31","author":[{"given":"Jun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Changzheng Hospital Second Military Medical University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102132"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2011.08.005"},{"key":"e_1_2_5_5_1","unstructured":"DesiderioJG NewmarkH CookTJ.Preliminary Oral Pharmacokinetics of the Potential Chemopreventive Agents Farnesol and Geraniol. 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