{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:44:58Z","timestamp":1768265098550,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T00:00:00Z","timestamp":1469577600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim:<\/jats:title><jats:p>Although metabolic factors such as obesity and hyperlipidemia were reported to be associated with high prevalence of colorectal neoplasm (CRN), their influence on the occurrence of CRN at surveillance colonoscopy has not been clarified. The purpose of this study was to analyze the association between metabolic factors and the risk of CRN at the time of surveillance colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>We reviewed the medical records of 1792 asymptomatic subjects (average 52.1\u2009years, 1233 male) who underwent screening and follow\u2010up surveillance colonoscopies. Fasting glucose level, fasting insulin level, hemoglobin A1c (HbA1c), lipid profile, high sensitivity C\u2010reactive protein, and colonoscopic findings at the time of baseline screening were analyzed to find any associations with the occurrence of CRN at the time of surveillance colonoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>The median interval between screening and surveillance colonoscopies was 3.34\u2009years. The 3\u2010 and 5\u2010year cumulative CRN incidences were 22.3% and 54.8%, respectively. Several metabolic factors such as hypertension, waist circumference, fasting insulin, fasting glucose, HbA1c, and triglyceride were associated with the occurrence of CRN in univariate analysis. Age, current alcohol drinker status, and high\u2010risk colonoscopy findings at baseline remained independent risk factors for CRN occurrence in multivariate analysis. High waist circumference was also an independent risk factor (hazard ratio 1.03, 95% CI 1.02\u20131.04; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p>Metabolic factors, especially waist circumference, affect CRN occurrence at the time of surveillance colonoscopy. The surveillance colonoscopy interval may be optimized based on metabolic factors and screening colonoscopy findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13286","type":"journal-article","created":{"date-parts":[[2016,1,5]],"date-time":"2016-01-05T06:26:42Z","timestamp":1451975202000},"page":"1273-1279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Metabolic factors affect the occurrence of colorectal neoplasm on surveillance colonoscopies"],"prefix":"10.1111","volume":"31","author":[{"given":"Hoonsub","family":"So","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungbong","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Applied Statistics Gachon University  Seongnam\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Won","family":"Park","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho\u2010Su","family":"Lee","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye\u2010Sook","family":"Chang","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaewon","family":"Choe","sequence":"additional","affiliation":[{"name":"Health Screening and Promotion Center, Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung\u2010Jae","family":"Myung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010Kyun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Sik","family":"Byeon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asan Medical Center, University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301969"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.232876"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.001"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1119646"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-304701"},{"key":"e_1_2_5_8_1","first-page":"485","article-title":"The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self\u2010Defense Forces health study","volume":"6","author":"Morita T","year":"2005","journal-title":"Asian Pac. 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