{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:13:04Z","timestamp":1772554384211,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,25]],"date-time":"2016-09-25T00:00:00Z","timestamp":1474761600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The role of screening endoscopy in primary gastric lymphoma (PGL) has not been investigated. This study aimed to evaluate the clinical characteristics and outcomes of PGLs detected by screening endoscopy in the high prevalence area of <jats:italic>Helicobacter pylori (H.\u2009pylori)<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study enrolled consecutive subjects who were diagnosed with PGL by endoscopic screening in Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea, between October 2003 and September 2013. The characteristics and outcome of screening\u2010detected patients (screening group) were compared with consecutive subjects diagnosed with PGL in the outpatient clinic (outpatient group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 105\u2009194 recipients of screening upper endoscopy, 52 (0.049%) were found to have PGL. The median age was 54.2\u2009years (range 23\u201379), and 65.4% were women. The proportion of PGL to gastric malignancy was 12.1% (52\/429) overall, but &gt;30% (25\/73) in middle\u2010aged (40\u201359) women. PGLs in the screening group were more likely to be mucosa\u2010associated lymphoid tissue lymphoma (98.1% <jats:italic>vs<\/jats:italic> 60.0%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and treated with <jats:italic>H.\u2009pylori<\/jats:italic> eradication alone (90.0% <jats:italic>vs<\/jats:italic> 48.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) than those in the outpatient group. Moreover, the screening group showed better 5\u2010year overall survival (100.0% <jats:italic>vs<\/jats:italic> 89.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.016) and progression\u2010free survival (94.9% <jats:italic>vs<\/jats:italic> 83.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.040) than the outpatient group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Korea, a high prevalence area of <jats:italic>H.\u2009pylori<\/jats:italic> infection, PGL seems more prevalent than in Western countries. Endoscopic screening may help to detect early stage <jats:italic>H.\u2009pylori<\/jats:italic>\u2010positive mucosa\u2010associated lymphoid tissue lymphoma. A high index of suspicion is needed, especially in middle\u2010aged women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13311","type":"journal-article","created":{"date-parts":[[2016,2,6]],"date-time":"2016-02-06T03:53:33Z","timestamp":1454730813000},"page":"1572-1583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical characteristics of primary gastric lymphoma detected during screening for gastric cancer in Korea"],"prefix":"10.1111","volume":"31","author":[{"given":"Hyo\u2010Joon","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-6576","authenticated-orcid":false,"given":"Changhyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seon Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Min","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong In","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.10.2656"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90280-G"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06444.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v16.i2.245"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2005.37.6.325"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27501"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01982.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12387"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21664"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802085395"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-104"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i6.697"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224949"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq182"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a059177"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.5671"},{"key":"e_1_2_6_19_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<693::AID-CNCR2820420241>3.0.CO;2-J"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2007.22.S.S3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01521.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70006-4"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(11)60587-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07424.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.6.912"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06705.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12033"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05639.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327489700400306"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2011.43.1.12"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603708"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.3.187"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.3.303"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-003-0241-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn120"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13311","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:15:14Z","timestamp":1696230914000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/jgh.13311"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13311","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"2015-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}