{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T12:07:30Z","timestamp":1778328450164,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Although endoscopic nasopancreatic drainage (ENPD) is useful for collecting samples for pancreatic juice cytology and for treating leakage of pancreatic juice and occlusive pancreatitis, placement of the ENPD catheter is associated with complications such as post\u2010endoscopic retrograde cholangiopancreatography pancreatitis (PEP). We investigated whether an ENPD catheter with a smaller diameter could reduce the incidence of complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients requiring placement of an ENPD catheter (<jats:italic>n<\/jats:italic>\u2009=\u2009254) were enrolled and randomly assigned to one of two catheter\u2010size groups: the 4\u2010Fr group or the 5\u2010Fr group. The incidence of PEP, cholangitis, and spontaneous catheter displacement and the suitability of pancreatic juice cytology samples were compared between groups. In addition, univariate and multivariate analyses were conducted on factors associated with PEP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of PEP was significantly lower in the 4\u2010Fr group compared with the 5\u2010Fr group (4.1% <jats:italic>vs<\/jats:italic> 12.4%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.021). The rate of cholangitis and spontaneous catheter displacement and the suitability of pancreatic juice cytology samples did not differ between groups. Multivariate analysis revealed that the risk of PEP was 3.7 times higher when using a 5\u2010Fr catheter than when using a 4\u2010Fr catheter (<jats:italic>P<\/jats:italic>\u2009=\u20090.019). In addition, the risk of PEP was 4.1 times higher in patients with an intraductal papillary mucinous neoplasm than in those without (<jats:italic>P<\/jats:italic>\u2009=\u20090.0049) and 4.6 times higher in patients aged &lt;65 than in those aged \u226565 (<jats:italic>P<\/jats:italic>\u2009=\u20090.0033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 4\u2010Fr catheter is as useful as a 5\u2010Fr catheter and is associated with a significantly lower incidence of PEP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13314","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T10:49:51Z","timestamp":1455187791000},"page":"1783-1789","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A comparison of 4\u2010Fr with 5\u2010Fr endoscopic nasopancreatic drainage catheters: A randomized, controlled trial"],"prefix":"10.1111","volume":"31","author":[{"given":"Teruo","family":"Mouri","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamito","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Serikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ishigaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima 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