{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:21:43Z","timestamp":1772792503548,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017635","name":"Korean College of Helicobacter and Upper Gastrointestinal Research Foundation","doi-asserted-by":"crossref","award":["Q1507041"],"award-info":[{"award-number":["Q1507041"]}],"id":[{"id":"10.13039\/501100017635","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The aim of this study was to compare HOXB7 expression level between gastric cancer and non\u2010cancerous gastric tissues. Additionally, the functional effects of HOXB7, including its pro\u2010migration or invasion and anti\u2010apoptosis roles, were evaluated in gastric cancer cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Both gene and protein expression levels of HOXB7 were examined in gastric cancer cell lines, and <jats:italic>HOXB7<\/jats:italic> expression was compared between primary or metastatic gastric cancer tissues and chronic gastritis or intestinal metaplasia tissues. Functional studies included a wound healing assay, a Matrigel invasion assay, and an Annexin\u2010V assay were performed, and Akt\/PTEN activity was measured by western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both gene and protein expression levels of HOXB7 could be clearly detected in various gastric cancer cell lines except MKN\u201028 cell. <jats:italic>HOXB7<\/jats:italic> expression was significantly higher in primary or metastatic gastric cancer tissues than in chronic gastritis or intestinal metaplasia tissues. <jats:italic>HOXB7<\/jats:italic> knockdown led to inhibition of cell invasion and migration, had an apoptotic effect, downregulated phosphor\u2010Akt, and upregulated PTEN in AGS and SNU\u2010638 cells. Reinforced expression of HOXB7 caused the opposite effects in MKN\u201028 and MKN\u201045 cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests that HOXB7 has an oncogenic role in gastric cancer, which might be related to the modulation of Akt\/PTEN activity to induce cell migration\/invasion and anti\u2010apoptotic effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13330","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T07:15:12Z","timestamp":1457766912000},"page":"1717-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The roles of HOXB7 in promoting migration, invasion, and anti\u2010apoptosis in gastric cancer"],"prefix":"10.1111","volume":"31","author":[{"given":"Moon Kyung","family":"Joo","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Korea University College of Medicine Guro Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Jae","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Korea University College of Medicine Guro Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Soon","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Korea University College of Medicine Guro Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beom Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Korea University College of Medicine Guro Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoon Jai","family":"Chun","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Korea University College of Medicine Anam Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Korea University College of Medicine Ansan Hospital  Ansan\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young\u2010Tae","family":"Bak","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Korea University College of Medicine Guro Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2826"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(09)88009-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc907"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701059104"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-113597"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2614"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0310"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.31902"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.032482"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.5.647"},{"key":"e_1_2_6_12_1","first-page":"621","article-title":"Quantitative expression of the homeobox and integrin genes in human gastric carcinoma","volume":"20","author":"Rossi Degl'Innocenti D","year":"2007","journal-title":"Int. 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