{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T21:40:02Z","timestamp":1748814002750,"version":"3.41.0"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T00:00:00Z","timestamp":1479859200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Very potent direct acting antivirals for the treatment of chronic hepatitis C virus infection were recently introduced into daily clinical practice. Currently, treatment uptake is hampered by their high costs, eliciting prioritization of treatment. We aimed to evaluate the direct medical costs during interferon (IFN)\u2010based antiviral treatment and the costs per sustained virological response (SVR) among patients with advanced hepatic fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included all consecutive patients with chronic hepatitis C virus infection and biopsy\u2010proven bridging fibrosis or cirrhosis (Ishak 4\u20136) treated with IFN\u2010based regimens in five hepatology units of tertiary care centers in Europe and Canada. Direct medical costs, expressed in 2013 Euros, during therapy were assessed. The components of care were quantified by three distinct categories: treatment, safety\/ monitoring, and complications. Cost per SVR was calculated by dividing the mean cost by the SVR rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 672 interferon\u2010based treatments administered to 455 patients were included. Total medical costs per patient were averaged to \u20ac14\u2009559 (95% confidence interval [CI], \u20ac13\u2009323\u2013\u20ac15\u2009836). The mean cost per SVR was \u20ac38\u2009514 (95% CI, \u20ac35\u2009244\u2013\u20ac41\u2009892). The costs per SVR were \u20ac26\u2009105 (95% CI, \u20ac23\u2009068\u2013\u20ac29\u2009296) for patients with a normal platelet count and \u20ac50\u2009907 (95% CI, \u20ac44\u2009151\u2013\u20ac59\u2009612) for patients with thrombocytopenia, with the costs per SVR of \u20ac74\u2009961 (95% CI, \u20ac55\u2009463\u2013\u20ac103\u2009541) among those patients with a platelet count below 100\u2009*\u200910<jats:sup>9<\/jats:sup>\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Because of the lower SVR rates, the cost per SVR of IFN\u2010based treatment increased when patients with more advanced liver disease were treated. Additional costs of IFN\u2010free therapy could be limited among these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13373","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:12:13Z","timestamp":1458371533000},"page":"1851-1859","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Real\u2010world medical costs of antiviral therapy among patients with chronic HCV infection and advanced hepatic fibrosis"],"prefix":"10.1111","volume":"31","author":[{"given":"Raoel","family":"Maan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remziye","family":"Zaim","sequence":"additional","affiliation":[{"name":"Institute for Medical Technology Assessment, Health Policy and Management Erasmus University Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriaan J","family":"van der Meer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan J","family":"Feld","sequence":"additional","affiliation":[{"name":"Liver Centre, Toronto Western &amp; General Hospital University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology Medical School Hannover Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Dufour","sequence":"additional","affiliation":[{"name":"Hepatology, Department of Clinical Research University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[{"name":"Department of Medicine II Saarland University Medical Center Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P","family":"Manns","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Endocrinology Medical School Hannover Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Zeuzem","sequence":"additional","affiliation":[{"name":"Medizinische Klinik 1 Klinikum der Johann Wolfgang Goethe\u2010Universit\u00e4t Frankfurt am Main Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina E","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry LA","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"},{"name":"Liver Centre, Toronto Western &amp; General Hospital University Health Network Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart J","family":"Veldt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J","family":"de Knegt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carin A","family":"Uyl\u2010de Groot","sequence":"additional","affiliation":[{"name":"Institute for Medical Technology Assessment, Health Policy and Management Erasmus University Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12248"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07642-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1002\/hep.1840360706","article-title":"Natural history of chronic hepatitis C","volume":"36","author":"Seeff LB","year":"2002","journal-title":"Hepatology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.067"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.03.009"},{"key":"e_1_2_6_7_1","first-page":"381","article-title":"Thrombocytopenia in chronic hepatitis C","volume":"19","author":"Olariu M","year":"2010","journal-title":"J. Gastrointest. Liver Dis."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.08.018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2010.01366.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22242"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.03.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(11)00022-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35950"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316366"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402869"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.04.021"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12256"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.144878"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12929"},{"key":"e_1_2_6_21_1","unstructured":"http:\/\/www.cbs.nl\/. Accessed on January 2015."},{"key":"e_1_2_6_22_1","unstructured":"http:\/\/www.cvz.nl\/binaries\/live\/cvzinternet\/hst_content\/nl\/documenten\/losse-publicaties\/handleiding-kostenonderzoek\u20102010.pdfAccessed on January 2015."},{"key":"e_1_2_6_23_1","unstructured":"https:\/\/compendium.ch\/home\/de?Platform=Desktop. Accessed on January 2015."},{"key":"e_1_2_6_24_1","unstructured":"https:\/\/www.zorginstituutnederland.nl\/. Accessed on January 2015."},{"key":"e_1_2_6_25_1","first-page":"745","article-title":"Costs of guideline\u2010based treatment of hepatitis B patients in Germany","volume":"50","author":"Stahmeyer JT","year":"2012","journal-title":"Z. Gastroenterol."},{"key":"e_1_2_6_26_1","unstructured":"http:\/\/www.nza.nl. Accessed on January 2015."},{"key":"e_1_2_6_27_1","unstructured":"http:\/\/www.commonwealthfund.org\/~\/media\/files\/publications\/fund\u2010report\/2015\/jan\/1802_mossialos_intl_profiles_2014_v7.pdf. Accessed on January 2016."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-10-200711200-00003"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.04.013"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.3111\/13696998.2011.562266"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02889.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21492"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.12.028"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80302-9"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23744"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27340"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.03.051"},{"key":"e_1_2_6_38_1","first-page":"25","article-title":"Interferon\u2010based therapies for hepatitis C: Utilization, costs, and outcomes","volume":"5","author":"Jonk YC","year":"2013","journal-title":"Am. J. Pharm. Benefits"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.03.014"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27757"},{"key":"e_1_2_6_41_1","first-page":"657","article-title":"Absenteeism and productivity among employees being treated for hepatitis C","volume":"17","author":"Brook RA","year":"2011","journal-title":"Am. J. Manag. Care"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12227"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13373","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T21:19:07Z","timestamp":1748812747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jgh.13373"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13373","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"type":"print","value":"0815-9319"},{"type":"electronic","value":"1440-1746"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"2015-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}