{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:52:49Z","timestamp":1760889169176},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Short bowel syndrome (SBS) is primarily characterized by malabsorption and malnutrition, resulting from loss of intestinal absorptive area following massive small bowel resection (SBR). Bile acids and the gut microbiota are functionally linked within the gut\u2010liver axis; however, SBS\u2010associated disturbances within the gut\u2010liver axis remain largely unexplored. The aim of this study was to characterize the evolution of bile acid alterations within the gut\u2010liver axis at both short\u2010term and long\u2010term time points and to relate these changes to alterations in colonic bacterial composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four\u2010week\u2010old piglets were assigned to 75% SBR, sham\u2010operation or non\u2010operation control groups. High throughput sequencing was employed to determine bacterial abundance in colonic content and ultra\u2010performance liquid chromatography used to determine the bile acid concentration of gall bladder, portal serum, and fecal samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bile acid complexity and relative abundance are altered in the SBS piglet model at two weeks post\u2010SBR, and these changes persisted at six weeks post\u2010SBR. Our examination of the microbial profile revealed an early and persistent loss in bacteria belonging to the <jats:italic>Clostridiales<\/jats:italic> order.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides evidence of an early and persistent disturbance of the bile acid profile throughout the entero\u2010hepatic circulation with an increase in the proportion of primary bile acids and a decrease in secondary bile acids following SBR. These changes were associated with a loss of bacteria belonging to the <jats:italic>Clostridiales<\/jats:italic> order consistent with a disturbance in the bile\u2010microbial axis following SBR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13383","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T16:46:26Z","timestamp":1459615586000},"page":"1946-1955","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Short bowel syndrome (SBS)\u2010associated alterations within the gut\u2010liver axis evolve early and persist long\u2010term in the piglet model of short bowel syndrome"],"prefix":"10.1111","volume":"31","author":[{"given":"Prue M","family":"Pereira\u2010Fantini","sequence":"first","affiliation":[{"name":"Intestinal Failure and Clinical Nutrition Research Group Murdoch Children's Research Institute  Parkville Victoria 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