{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T08:14:41Z","timestamp":1765354481678},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Video\u2010capsule endoscopy (VCE) has shown that intestinal ulcers are common in non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs) users, although the mechanisms and management have not been clearly defined. To explore the contribution of oxidative stress and potential of anti\u2010oxidants for NSAIDs\u2010induced intestinal ulcers, we assessed human serum oxidative stress balance and the effect of anti\u2010oxidants using a mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 30 NSAIDs users (17 aspirin and 13 non\u2010aspirin users) received VCE. Serum reactive oxygen metabolite (d\u2010ROM) and antioxidative OXY\u2010adsorbent test (OXY) were measured. The indomethacin (IND)\u2010induced mouse intestinal ulcer model was used to assess the effect of anti\u2010oxidants. Eight\u2010week\u2010old mice were divided into four groups; control diet and diet including IND (N group), IND and L\u2010carnitine (NC group), and IND and vitamin E (NE group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum OXY levels among non\u2010aspirin users were lower in the mucosal injuries positive group than the negative group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). In the mouse models, the degree of mucosal injuries was lower in NC and NE than N (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Serum d\u2010ROM levels were lower in NC and NE than N (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and OXY levels were higher in NC than N and NE (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The degeneration of intestinal mitochondria was mild in NC and NE. The serum KC\/CXCL\u20101 level and hepatic expression of the anti\u2010oxidant molecule Gpx4 were lower in NC than N.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Non\u2010aspirin NSAID\u2010induced intestinal ulcers are related to decreased anti\u2010oxidative stress function. Anti\u2010oxidants, especially L\u2010carnitine, are good candidates for intestinal ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13424","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T14:38:11Z","timestamp":1461767891000},"page":"136-145","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Oxidative stress controlling agents are effective for small intestinal injuries induced by non\u2010steroidal anti\u2010inflammatory drugs"],"prefix":"10.1111","volume":"32","author":[{"given":"Yoshiyasu","family":"Kono","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Takaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Onji","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakuma","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joichiro","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fukuyama Medical Center  Fukuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayo","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fukuyama City Hospital  Fukuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tsuyama Chuo Hospital  Tsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012060-00010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07273-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00603-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00499.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.06.075"},{"key":"e_1_2_6_7_1","first-page":"25","article-title":"Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin\u2010induced small intestinal lesions in rats","volume":"50","author":"Konaka A","year":"1999","journal-title":"J. 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