{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:12:43Z","timestamp":1770977563170,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Celiac disease is a multi\u2010systemic disease, which can affect any organ system including liver. However, the prevalence of celiac disease and the sensitivity and specificity of anti\u2010tissue transglutaminase (anti\u2010tTG) in diagnosing celiac disease in patients with cirrhosis of liver is not well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We screened a cohort of patients with chronic liver disease for an associated diagnosis of celiac disease. Anti\u2010tTG was carried out in all patients, and those with a high value were subjected to duodenal biopsy for histological confirmation. In patients where biopsy was contraindicated or refused, anti\u2010endomysial antibody (anti\u2010EMA) was tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of a total of 595 patients with chronic liver disease, high levels of anti\u2010tTG were noted in 150 (25.2%) patients, and celiac disease was diagnosed in 14 patients (2.4%). Celiac autoimmunity (high levels of both anti\u2010tTG and anti\u2010EMA) was noted in seven patients (1.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although a large number of cirrhotic patients have high levels of anti\u2010tTG, duodenal histology and\/or anti\u2010EMA is normal in majority of these patients. This suggests high false positivity of anti\u2010tTG in patients with cirrhosis and highlights the need of duodenal biopsy for histological confirmation of the diagnosis of celiac disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13474","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:26:44Z","timestamp":1466987204000},"page":"446-450","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prevalence and clinical significance of IgA anti\u2010tissue transglutaminase antibodies in patients with chronic liver disease"],"prefix":"10.1111","volume":"32","author":[{"given":"Ajit","family":"Sood","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College  Ludhiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manbir Singh","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dayanand Medical College  Ludhiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramit","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dayanand Medical College  Ludhiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Midha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dayanand Medical College  Ludhiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dayanand Medical College  Ludhiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dayanand Medical College  Ludhiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dayanand Medical College  Ludhiana Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Sharma","sequence":"additional","affiliation":[{"name":"College of Nursing All India Institute of Medical Sciences  Rishikesh Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)70237-4"},{"key":"e_1_2_6_3_1","first-page":"167","article-title":"Should we look for celiac disease among all patients with liver function test abnormalities?","volume":"3","author":"Emami MH","year":"2012","journal-title":"Int. J. Prev. Med."},{"key":"e_1_2_6_4_1","first-page":"156","article-title":"Nonalcoholic steatohepatitis, obesity and celiac disease","volume":"22","author":"Sood A","year":"2003","journal-title":"Indian J. Gastroenterol. Off. J. Indian Soc. Gastroenterol."},{"issue":"11","key":"e_1_2_6_5_1","first-page":"1186","article-title":"Massive hepatic steatosis complicating adult celiac disease: report of a case and review of the literature","volume":"82","author":"Naschitz JE","year":"1987","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.05.020"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37302"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31016-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/17.8.437"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23258"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22261"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23042"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199910000-00019"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301346"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20021234"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06606.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04281.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.398"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-014-0501-z"},{"key":"e_1_2_6_21_1","first-page":"941","article-title":"Prevalence and clinical significance of immunoglobulin A antibodies against tissue transglutaminase in patients with diverse chronic liver diseases","volume":"12","author":"Germenis AE","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2005.01.015"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.506"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200204000-00006"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.05.001"},{"key":"e_1_2_6_26_1","first-page":"510","article-title":"Influence of portal pressure change on intestinal permeability in patients with portal hypertension","volume":"1","author":"Xu WH","year":"2002","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"issue":"2","key":"e_1_2_6_27_1","first-page":"G281","article-title":"A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF\u2010kappaB","volume":"272","author":"Mirza A","year":"1997","journal-title":"Am. J. Physiol."},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00135-0"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04004.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22161"},{"key":"e_1_2_6_31_1","first-page":"401","article-title":"Tissue transglutaminase antibodies: is sensitivity more important than specificity?","volume":"33","author":"Biagi F","year":"2001","journal-title":"Dig. Liver Dis. Off. J. Ital. Soc. Gastroenterol. Ital. Assoc. Study Liver"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T22:51:05Z","timestamp":1696459865000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/jgh.13474"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13474","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"2016-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}