{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:00:55Z","timestamp":1782482455459,"version":"3.54.5"},"reference-count":75,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Early Career Seed Grant","award":["ECSG13025"],"award-info":[{"award-number":["ECSG13025"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis to identify personal, lifestyle, and tumor\u2010related risk factors for metachronous colorectal cancer (CRC) and polyp.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant studies were identified by searching MEDLINE, Web of Science and Cochrane Central Register through 15 May 2016. Estimates for associations were summarized using random effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five studies were included in the review. For individuals who had a CRC resection, having a synchronous polyp was a risk factor for metachronous CRC or polyp (relative risk [RR], 2.04; 95% confidence interval [CI], 1.48\u20132.82) and having a synchronous CRC (RR, 1.90; 95% CI, 1.25\u20132.91) and proximally located CRC (RR, 2.12; 95% CI, 1.24\u20133.64) were risk factors for metachronous CRC. For individuals who had a polypectomy, larger size (RR, 4.26; 95% CI, 2.11\u20138.57) or severe dysplasia of the initial polyp (RR, 5.15; 95% CI, 2.02\u201313.14), and having a synchronous polyp (RR, 2.52; 95% CI, 1.35\u20134.73) were risk factors for metachronous CRC; and a family history of CRC (RR, 1.90; 95% CI, 1.26\u20132.87), having a synchronous polyp (RR, 2.47; 95% CI, 1.74\u20133.50) and a larger size (RR, 1.49; 95% CI, 1.03\u20132.15) and proximal location of the initial polyp (RR, 1.20; 95% CI, 1.02\u20131.40) were risk factors for metachronous polyp. Meta\u2010regression showed duration of follow\u2010up was not a source of heterogeneity for most associations. There was no evidence that lifestyle factors were associated with metachronous CRC or polyp risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A comprehensive list of risk factors identified for metachronous CRC or polyp may have important clinical implications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13476","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T22:47:34Z","timestamp":1467240454000},"page":"301-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk factors for metachronous colorectal cancer or polyp: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Harindra","family":"Jayasekara","sequence":"first","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health The University of Melbourne  Parkville Victoria 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