{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T18:04:40Z","timestamp":1789236280916,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Endoscopic ultrasonography guided\u2010celiac plexus neurolysis relieves pain in patients with pancreatic cancer but with often suboptimal and transient results. The study aims to compare the efficacy and safety of endoscopic ultrasound\u2010guided tumor ethanol ablation combined with celiac plexus neurolysis with respect to celiac plexus neurolysis alone for pain management in patients with pancreatic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 123 patients with unresectable pancreatic cancer referred to our Institution between 2006 and 2014, 58 treated with endoscopic ultrasound\u2010guided celiac plexus neurolysis (Group 1) and 65 with the combined approach (Group 2) were compared. Logistic regression models were applied to identify predictors of pain relief.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two groups presented similar baseline clinical and tumoral parameters. Pre\u2010procedural visual analog scale score was 7 in both groups (<jats:italic>P<\/jats:italic>\u2009=\u20090.8), and tumor max diameter was 38\u2009mm (range 25\u201359) in Group 1 and 43\u2009mm (22\u201359) in Group 2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.4). The combined treatment increased pain relief and complete pain response rate (<jats:italic>P<\/jats:italic>\u2009=\u20090.005 and 0.003, respectively). Median duration of pain relief was 10 (7\u201314) and 18 (13\u201320) weeks in the two groups, respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). At multivariate regression, initial visual analog scale score and endoscopic technique adopted resulted significantly associated with pain relief. No severe treatment\u2010related adverse events were reported. Median overall survival was 6.5\u2009months (5.1\u20138.6) in Group 1 and 8.3\u2009months (6\u201311.4) in Group 2 (<jats:italic>P<\/jats:italic>\u2009=\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endoscopic ultrasound\u2010guided tumor ablation combined with celiac plexus neurolysis appears to be superior to celiac plexus neurolysis alone in terms of pain control and overall survival.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13478","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T22:47:34Z","timestamp":1467240454000},"page":"439-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Echoendoscopic ethanol ablation of tumor combined with celiac plexus neurolysis in patients with pancreatic adenocarcinoma"],"prefix":"10.1111","volume":"32","author":[{"given":"Antonio","family":"Facciorusso","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Medical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Di Maso","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Serviddio","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Larghi","sequence":"additional","affiliation":[{"name":"Digestive Endoscopic Unit Catholic University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Costamagna","sequence":"additional","affiliation":[{"name":"Digestive Endoscopic Unit Catholic University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Muscatiello","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medical Sciences University of Foggia  Foggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1404198"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480000700201"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/004947550203200413"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70047-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0651-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181bb854d"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.339"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.2750"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.170428"},{"issue":"4","key":"e_1_2_7_11_1","first-page":"501","article-title":"Tridimensional (3D) endoscopic ultrasound \u2013 a pictorial review","volume":"18","author":"Saftoiu A","year":"2009","journal-title":"J. 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