{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:46:41Z","timestamp":1762145201488},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"SK Life Science, Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Prokinetics have been considered the first\u2010line medicine for treating delayed gastric emptying. The aim of this study was to explore the effects and mechanisms of a new 5\u2010HT<jats:sub>4<\/jats:sub> receptor agonist, YKP10811, on gastric motility in dogs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four experiments were performed in dogs: (i) dose\u2013response effects of YKP10811 on liquid gastric emptying; (ii) effects and mechanisms of YKP10811 on solid gastric emptying delayed by glucagon; (iii) effects of low\u2010dose YKP10811 on antral contractions; and (iv) effects of low\u2010dose YKP10811 on gastric accommodation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No adverse events or cardiac dysrhythmia was noted. (i) High\u2010dose YKP10811 (30\u2009mg\/kg) accelerated liquid gastric emptying from 15 to 90\u2009min without inducing adverse events or cardiac dysrhythmia. YKP10811 at low doses (0.3, 1, and 3\u2009mg\/kg) accelerated gastric emptying in a dose\u2010dependent manner. (ii) YKP10811 (0.1\u2009mg\/kg), but not tegaserod (0.3\u2009mg\/kg), significantly accelerated glucagon\u2010induced delayed gastric emptying of solid, and the effect was completely blocked by GR113808. (iii) YKP10811 (0.3\u2009mg\/kg) enhanced antral contractions. (iv) YKP10811 did not alter gastric accommodation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>YKP10811 seems to improve antral contractions and accelerate gastric emptying without altering gastric accommodation in dogs via the 5\u2010HT<jats:sub>4<\/jats:sub> mechanism and is substantially more potent than tegaserod. No adverse events were noted at a dose 300 times the lowest effective dose. YKP10811 may have a therapeutic potential for gastroparesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13490","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T09:06:15Z","timestamp":1468573575000},"page":"625-630","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prokinetic effects of a new 5\u2010HT<sub>4<\/sub> agonist, YKP10811, on gastric motility in dogs"],"prefix":"10.1111","volume":"32","author":[{"given":"Jieyun","family":"Yin","sequence":"first","affiliation":[{"name":"Division of Gastroenterology University of Texas Medical Branch  Galveston Texas USA"},{"name":"VA Medical Center Veterans Research and Education Foundation  Oklahoma Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[{"name":"VA Medical Center Veterans Research and Education Foundation  Oklahoma Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gengqing","family":"Song","sequence":"additional","affiliation":[{"name":"VA Medical Center Veterans Research and Education Foundation  Oklahoma Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Sil","family":"Han","sequence":"additional","affiliation":[{"name":"Non\u2010Clinical Development Group, Division of Pharm Development SK Life Science, Inc.  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