{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:32:57Z","timestamp":1771918377486,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NovoNordisk Foundation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Early detection of renal dysfunction in cirrhosis is important, and several renal biomarkers have been put forward. Neutrophil gelatinase\u2010associated lipocalin (NGAL) and cystatin C are markers of renal dysfunction, but relations to splanchnic and systemic hemodynamics and kinetics are sparsely studied in cirrhosis.<\/jats:p><jats:p>In patients with cirrhosis and portal hypertension, we studied plasma levels and renal, hepatic, and peripheral extraction of NGAL and cystatin C and relations to patients characteristics, liver dysfunction, and hemodynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five cirrhotic patients (Child class A\/B\/C:15\/15\/15) and 15 controls were evaluated with a full clinical, biochemical, and hemodynamic assessment. Urine and regional plasma concentrations of NGAL and cystatin C were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in circulating or hepatic NGAL or cystatin C between all patients and controls but a trend towards increased levels with increasing Child class. In addition, there was a significant renal but no hepatic or systemic extraction of both NGAL and cystatin C (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><jats:p>Plasma NGAL correlated with glomerular filtration rate (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.56, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001), and hepatic venous pressure gradient (<jats:italic>r<\/jats:italic>\u2009=\u20090.34,<jats:italic>P<\/jats:italic>\u2009=\u20090.02) and urinary NGAL correlated with heart rate (<jats:italic>r<\/jats:italic>\u2009=\u20090.58, <jats:italic>P<\/jats:italic>=\u20090.007), blood pressure (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.46, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), cardiac output (<jats:italic>r<\/jats:italic>\u2009=\u20090.45, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and systemic vascular resistance (SVR) (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.48, p\u2009&lt;\u20090.05). Plasma cystatin C correlated with hepatic venous pressure gradient (<jats:italic>r<\/jats:italic>\u2009=\u20090.45, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.005), blood pressure (\u22120.40, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), and glomerular filtration rate (<jats:italic>r<\/jats:italic>\u2009=\u20090.98, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Extractions of NGAL and cystatin C levels seem largely unaffected by the severity of liver disease in cirrhosis with a renal extraction. These biomarkers therefore have the potential of being both valuable in diagnosing renal failure and reflecting the degree of portal hypertension and systemic haemodynamic changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13492","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T11:31:48Z","timestamp":1469014308000},"page":"473-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Neutrophil gelatinase\u2010associated lipocalin and cystatin C in cirrhosis and portal hypertension: Relations to organ extraction and dysfunction"],"prefix":"10.1111","volume":"32","author":[{"given":"Preete Kapisha","family":"Hurry","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Center for Functional and Diagnostic Imaging and Research  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen Hjelm","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Bendtsen","sequence":"additional","affiliation":[{"name":"Gastro Unit, Medical Division, Hvidovre Hospital, Faculty of Health Sciences University of Copenhagen  Hvidovre Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Center for Functional and Diagnostic Imaging and Research  Hvidovre 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