{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:51:54Z","timestamp":1787986314555,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Innovation Fund of Shanghai Committee of Science and Technology","award":["15411950501"],"award-info":[{"award-number":["15411950501"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Current guidelines recommend injection of cyanoacrylate as first\u2010line therapy to prevent gastric variceal rebleeding. The method still poses a risk of ectopic embolism, which possibly correlates with the volume of cyanoacrylate used. In this trial, we evaluated the short\u2010term efficacy and safety of tissue adhesive injection combined with lauromacrogol for treating gastric varices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients admitted to our hospital for variceal hemorrhage were enrolled and blindly randomized into two treatment groups: lauromacrogol group (lauromacrogol\u2010cyanoacrylate\u2010lauromacrogol) and lipiodol group (lipiodol\u2010cyanoacrylate\u2010lipiodol). Patient follow\u2010up was 6\u2009months. Primary outcome was rebleeds, and secondary outcomes were mortality, gastric varices eradication, and treatment\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between March 6, 2013 and October 16, 2013, 96 patients met the criteria. Two cases were lost to follow\u2010up, and all treated cases were successful. No procedural\u2010related adverse events were observed in either group. Cyanoacrylate volumes used in the lauromacrogol group were significantly less than those of the lipiodol group (0.9\u2009\u00b1\u20090.5 <jats:italic>vs<\/jats:italic> 2.0\u2009\u00b1\u20091.2\u2009mL, <jats:italic>P<\/jats:italic>\u2009=\u20090.000). Eleven patients developed upper gastrointestinal rebleeding, which did not show significant difference between groups. On multivaritate analysis, portal venous thrombosis and fever were potential risk factors of rebleeding. Treatment failure, complications, gastric varices obturation, and survival did not differ between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tissue adhesives combined with lauromacrogol is a safe therapeutic option for gastric varices, with comparably less cyanoacrylate volume used. Because of the small number of study patients, it cannot be proven to have better efficacy than without lauromacrogol. Multicenter studies with larger patient groups are necessary.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13496","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T15:52:50Z","timestamp":1469029970000},"page":"631-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Endoscopic cyanoacrylate injection with or without lauromacrogol for gastric varices: A randomized pilot study"],"prefix":"10.1111","volume":"32","author":[{"given":"Xiao\u2010Qing","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Li","family":"Ma","sequence":"additional","affiliation":[{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Jen","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Xiao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian\u2010Cheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Yao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160607"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i8.1247"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70186-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.05.022"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0973-6883(12)60088-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.02.050"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000177012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)00341-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35312"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.05.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(97)70202-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03992.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000499"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-012-0191-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/276273"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2014.29.4.437"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.06.015"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4945"},{"key":"e_1_2_6_20_1","first-page":"155","article-title":"Long\u2010term efficacy and safety of N\u2010butylcyanoacrylate in endoscopic treatment of gastric varices","volume":"31","author":"Choudhuri G","year":"2010","journal-title":"Trop. 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