{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:02:07Z","timestamp":1767844927638,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Whether concomitant therapy is superior to sequential therapy (ST) as first\u2010line therapy of <jats:italic>Helicobacter pylori<\/jats:italic> in areas with high clarithromycin resistance remains controversial. The aim of this study was to compare the efficacy and tolerability of 10\u2010 or 14\u2010day ST with 10\u2010 or 14\u2010day concomitant therapy (CT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective randomized study comparing 10\u2010 or 14\u2010day ST with 10\u2010 or 14\u2010day CT. The ST\u201010 and ST\u201014 groups received pantoprazole 40\u2009mg and amoxicillin 1\u2009g twice a day for the first 5 and 7\u2009days followed by pantoprazole 40\u2009mg, clarithromycin 500\u2009mg, and metronidazole 500\u2009mg twice a day for the remaining 5 and 7\u2009days, respectively. The CT\u201010 and CT\u201014 groups received pantoprazole 40\u2009mg, amoxicillin 1\u2009g, clarithromycin 500\u2009mg, and metronidazole 500\u2009mg twice daily for 10 and 14\u2009days, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred forty\u2010one patients were randomly allocated to the four groups. The modified intention\u2010to\u2010treat eradication rates of ST\u201010, ST\u201014, CT\u201010, and CT\u201014 were 91.7%, 91.2%, 94.2%, and 98.5%, respectively. The corresponding per protocol eradication rates were 91.4%, 91.0%, 95.6%, and 98.5%. There was no difference in compliance and adverse events in the four groups. Eradication rates increased sequentially with statistical significance in the following order: ST\u201010, ST\u201014, CT\u201010, and CT\u201014 (<jats:italic>P<\/jats:italic>\u2009=\u20090.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All four regimens achieved eradication rates &gt;90% in per protocol analyses in a country with high clarithromycin resistance. There was no difference in tolerability among the four regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13510","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T18:56:37Z","timestamp":1470768997000},"page":"589-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Randomized clinical trial comparing 10\u2010 or 14\u2010day sequential therapy and 10\u2010 or 14\u2010day concomitant therapy for the first line empirical treatment of <i>Helicobacter pylori<\/i> infection"],"prefix":"10.1111","volume":"32","author":[{"given":"Sung Min","family":"Park","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Incheon St. Mary's Hospital Catholic University of Korea  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Incheon St. Mary's Hospital Catholic University of Korea  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Incheon St. Mary's Hospital Catholic University of Korea  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong\u2010Seon","family":"Ji","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Incheon St. Mary's Hospital Catholic University of Korea  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwang","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, College of Medicine, Incheon St. Mary's Hospital Catholic University of Korea  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01109.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61159-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2006.00460.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302084"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01393.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05982.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.022111"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192757"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13497"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.125658"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.555"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00671.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04770.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/MCG.0b013e3181c8a1a3","article-title":"Sequential therapy for Helicobacter pylori eradication: a critical review","volume":"44","author":"Gisbert JP","year":"2010","journal-title":"J. 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