{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:42:02Z","timestamp":1782798122459,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea, Republic of Korea","award":["2008-0062279"],"award-info":[{"award-number":["2008-0062279"]}]},{"name":"National Research Foundation of Korea, Republic of Korea","award":["2015R1A2A1A13001849"],"award-info":[{"award-number":["2015R1A2A1A13001849"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Compromised protein folding capacity in the endoplasmic reticulum (ER) leads to a protein traffic jam that produces a toxic environment called ER stress. However, the ER smartly handles such a critical situation by activating a cascade of proteins responsible for sensing and responding to the noxious stimuli of accumulated proteins. The ER protein load is higher in secretory cells, such as liver hepatocytes, which are thus prone to stress\u2010mediated toxicity and various diseases, including alcohol\u2010induced liver injury, fatty liver disease, and viral hepatitis. Therefore, we discuss the molecular cues that connect ER stress to hepatic diseases. Moreover, we review the literature on ER stress\u2010regulated miRNA in the pathogenesis of liver diseases to give a comprehensive overview of mechanistic insights connecting ER stress and miRNA in the context of liver diseases. We also discuss currently discovered regulated IRE1 dependent decay in regulation of hepatic diseases.<\/jats:p>","DOI":"10.1111\/jgh.13619","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T02:22:37Z","timestamp":1477275757000},"page":"981-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Endoplasmic reticulum stress in the regulation of liver diseases: Involvement of Regulated IRE1<b>\u03b1<\/b> and <b>\u03b2<\/b>\u2010dependent decay and miRNA"],"prefix":"10.1111","volume":"32","author":[{"given":"Harun\u2010Or","family":"Rashid","sequence":"first","affiliation":[{"name":"Department of Pharmacology and New Drug Development Institute, Medical School Chonbuk National University  Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun\u2010Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and New Drug Development Institute, Medical School Chonbuk National University  Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghupatil","family":"Junjappa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and New Drug Development Institute, Medical School Chonbuk National University  Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung\u2010Ryong","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School and Institute of Science and Technology DGIST  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Jung","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and New Drug Development Institute, Medical School Chonbuk National University  Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0396.2007.00752.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405522200"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/841362"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7383-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2003.07.001"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.08.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.22.010305.104656"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013169"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200903014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.09.004"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1226191"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq452"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.02.008"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00076"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111298"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.153.5.1011"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2015.1091141","article-title":"ER stress: autophagy induction, inhibition and selection","volume":"11","author":"Rashid HO","journal-title":"Autophagy"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1091141"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600106"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.2.152"},{"key":"e_1_2_8_23_1","first-page":"487","article-title":"Silencing of lipid metabolism genes through IRE1alpha\u2010mediated mRNA decay lowers plasma lipids in mice","volume":"16","author":"So JS","journal-title":"Cell Metab."},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/emboj.2011.52","article-title":"The unfolded protein response transducer IRE1alpha prevents ER stress\u2010induced hepatic steatosis","volume":"30","author":"Zhang K","journal-title":"EMBO J."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.10.022"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1091\/mbc.e11-06-0510","article-title":"The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress","volume":"22","author":"Teske BF","journal-title":"Mol. 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