{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:37:20Z","timestamp":1764873440008},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To guide selection of optimal screening strategies for advanced colorectal neoplasia (ACRN), we evaluated the screening performances of sigmoidoscopy, fecal immunochemical test (FIT), and the Asia\u2010Pacific Colorectal Screening (APCS) system, as well as combinations of these techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the records of participants who had undergone a colonoscopy and FIT as part of a comprehensive health\u2010screening program. Results of sigmoidoscopy were estimated from lesions under colonoscopic examination. The screening strategies were classified as sigmoidoscopy\u2010based, FIT\u2010based, and APCS\u2010based. The sensitivity and reduction of number needed to colonoscope (NNScope) of each screening strategy were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 23\u00a0023 participants, 398 (1.7%) had ACRN. To predict the presence of ACRN, sigmoidoscopy was the most effective method (odds ratio [OR]: 22.96, 95% confidence interval [CI]: 18.26\u201329.07), followed by FIT (OR: 7.18, 95% CI: 5.28\u20139.68) and APCS (high risk [\u22654] OR: 2.59, 95% CI: 1.87\u20133.58; moderate risk [2\u20133] OR: 1.66, 95% CI: 1.28\u20132.17). Regarding sigmoidoscopy\u2010based strategies, \u201csigmoidoscopy positive alone\u201d and \u201csigmoidoscopy positive or APCS \u22654\u201d were optimal strategies (reduction of NNScope: 79\u201386%; sensitivity: 73\u201378%). In the case of FIT\u2010based strategies, \u201cFIT positive or APCS \u22654\u201d was the optimal strategy (reduction of NNScope: 72%; sensitivity: 37%). With regard to the APCS system only, \u201cAPCS \u22652\u201d and \u201cAPCS \u22654\u201d were recommended as sensitivity\u2010preferred and reduction in NNScope\u2010preferred strategies, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The performance in ACRN prediction differs among screening methods (sigmoidoscopy, FIT, and APCS). Among the various single or combined screening strategies, several specific strategies can be chosen depending on medical resources, financial budgets, and screenee preference.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13634","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T20:26:42Z","timestamp":1478550402000},"page":"1003-1010","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identifying the optimal strategy for screening of advanced colorectal neoplasia"],"prefix":"10.1111","volume":"32","author":[{"given":"Yoon Suk","family":"Jung","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Hyuk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University Guri Hospital, Hanyang University College of Medicine  Guri Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Il","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong Il","family":"Sohn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2014.12.4.268"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.418"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2015.13.4.326"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-73"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn026"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.6828"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3332"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.8266"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji175"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3583-2"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.249"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.056"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.221168"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000102"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.11.042"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.11.035"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.06.013"},{"key":"e_1_2_5_19_1","first-page":"70","article-title":"Alternatives to colonoscopy for population\u2010wide colorectal cancer screening","volume":"22","author":"Leung WC","year":"2016","journal-title":"Hong Kong Med. 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