{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:34:06Z","timestamp":1761863646108},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,27]],"date-time":"2017-04-27T00:00:00Z","timestamp":1493251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005407","name":"Food and Health Bureau","doi-asserted-by":"publisher","award":["CU\u201015\u2010A8"],"award-info":[{"award-number":["CU\u201015\u2010A8"]}],"id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>In Asia\u2010Pacific where cost is a major concern, peginterferon plus ribavirin (PR) often remain as the standard of care in chronic hepatitis C (CHC) treatment, while the direct\u2010acting antivirals (DAAs) are commonly recommended as retreatment. Newer DAAs can achieve a sustained virological response (SVR) of nearly 100% with pan\u2010genotypic coverage, that is \u201cHighly Effective DAAs.\u201d We aimed to investigate the most desirable cost range for the Highly Effective DAAs using Hong Kong as an example.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Markov modeling was performed using PR as the reference strategy. The cost\u2010effectiveness of the Highly Effective DAAs was compared with sofosbuvir\u2010PR (first\u2010line and rescue) and boceprevir\u2010PR therapies. A 50\u2010year\u2010old genotype 1b hepatitis C virus (HCV) infected treatment\u2010na\u00efve patient with METAVIR F3 was used as the base case scenario to reflect the commonest HCV genotype in Hong Kong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of PR would incur a lifetime cost of US$35,854 and effectiveness of 14.85 quality\u2010adjusted life\u2010year (QALY). Sofosbuvir\u2010PR as first\u2010line treatment was dominated by other regimes. If Sofosbuvir\u2010PR rescue therapy was used, the drug cost of Highly Effective DAAs should be set below US$43,553, with a cost\u2010effectiveness ratio (CER) of US$3035\/QALY compared with PR. In regions where Boceprevir\u2010PR was still used as first\u2010line therapy, the desirable drug cost of Highly Effective DAAs would be below US$56,985 to achieve a CER of US$5427\/QALY.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most desirable costs of the Highly Effective DAAs would be below US$43,553 if Sofosbuvir\u2010PR rescue therapy is used and below US$56,985 if Boceprevir\u2010PR therapy is used.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13638","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T17:57:29Z","timestamp":1478541449000},"page":"1071-1078","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cost\u2010effectiveness of the highly effective direct\u2010acting antivirals in the treatment of chronic hepatitis C in Hong Kong"],"prefix":"10.1111","volume":"32","author":[{"given":"Angeline Oi\u2010Shan","family":"Lo","sequence":"first","affiliation":[{"name":"Institute of Digestive Disease  Hong Kong"},{"name":"Department of Medicine and Therapeutics  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry Lik\u2010Yuen","family":"Chan","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease  Hong Kong"},{"name":"Department of Medicine and Therapeutics  Hong Kong"},{"name":"State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent Wai\u2010Sun","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease  Hong Kong"},{"name":"Department of Medicine and Therapeutics  Hong Kong"},{"name":"State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Lai\u2010Hung","family":"Wong","sequence":"additional","affiliation":[{"name":"Institute of Digestive Disease  Hong Kong"},{"name":"Department of Medicine and Therapeutics  Hong Kong"},{"name":"State Key Laboratory of Digestive Disease The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15109-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26141"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000087259"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa020047","article-title":"Peginterferon alfa\u20102a plus ribavirin for chronic hepatitis C virus infection","volume":"347","author":"Fired MW","year":"2002","journal-title":"N. 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