{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:59:47Z","timestamp":1792425587586,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p><jats:italic>Helicobacter pylori<\/jats:italic> (HP) infection can influence the inflammatory and immune responses in the gut and may therefore play a role in the development of gluten\u2010related enteropathy in genetically susceptible individuals. Our objective was to assess the relationship between celiac disease and HP infection in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children (1\u201318\u00a0years) diagnosed as celiac disease (CD) (<jats:italic>n<\/jats:italic>\u00a0=\u00a0324) with submission of gastric and duodenal biopsies and duodenal histology having Marsh grade III features were eligible for the study. Non\u2010celiac patients referred for endoscopy were selected as controls. We studied proportion of HP prevalence in children with confirmed CD as compared with HP prevalence in reference group comprising non\u2010celiac children referred for endoscopy. We also evaluated predictors of HP infection in children with celiac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 324 participants with CD, gastric HP was seen in 37 (11.4%) patients. The prevalence of HP in patients without CD (50%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) was significantly higher. Among patients with CD, HP infection was most frequent in patients with Marsh IIIa. In the stepwise regression analysis for risk factors of HP infection in CD patients: presence of gastritis, hemoglobin, and absence of scalloping were found to be independent predictors in a multivariate setup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Celiac disease and gastric HP infection have inverse relationship that raises the question whether development of HP infection confers protection against CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13654","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T19:21:57Z","timestamp":1479324117000},"page":"1178-1182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Celiac disease and <i>Helicobacter pylori<\/i> infection in children: Is there any Association?"],"prefix":"10.1111","volume":"32","author":[{"given":"Manish","family":"Narang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology GB Pant Institute of Post Graduate Medical Education and Research  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarender Singh","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology GB Pant Institute of Post Graduate Medical Education and Research  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology GB Pant Institute of Post Graduate Medical Education and Research  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatinderpal","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology GB Pant Institute of Post Graduate Medical Education and Research  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology GB Pant Institute of Post Graduate Medical Education and Research  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra K","family":"Saran","sequence":"additional","affiliation":[{"name":"Department of Pathology GB Pant Institute of Post Graduate Medical Education and Research  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.22123"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.74.3.209"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-006-0023-7"},{"key":"e_1_2_5_5_1","first-page":"191","article-title":"Celiac disease: extraintestinal manifestations, associated diseases, and complications","volume":"49","author":"Somech R","year":"2002","journal-title":"Adv. Pediatr."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.02.030"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2016.04.032"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90126-J"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00621.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200012120-00004"},{"key":"e_1_2_5_11_1","first-page":"427","article-title":"Peptic ulcer disease, irritable bowel syndrome and constipation in two populations in Iran","volume":"7","author":"Massarrat S","year":"1995","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800404"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.45.7.597"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.3.207"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90819-M"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199902000-00003"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655201317097137"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0950-3528(95)90032-2"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_5_20_1","first-page":"761","article-title":"Helicobacter pylori in Children: an Indian perspective","volume":"44","author":"Poddar U","year":"2007","journal-title":"Indian Pediatr."},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt234"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01082.x"},{"key":"e_1_2_5_23_1","first-page":"115","article-title":"Clinical and histological presentation of Helicobacter pylori and gluten related gastroenteropathy","volume":"14","author":"Rostami Nejad M","year":"2011","journal-title":"Arch. Iran. Med."},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082009001200004"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802101846"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199902000-00009"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03421.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13249"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.8.821"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45041"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303018"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.12.7481"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu054"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.137539"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i21.2923"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.397"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1001110"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13654","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13654","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgh.13654","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:40:49Z","timestamp":1694212849000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,30]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/jgh.13654"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13654","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,30]]},"assertion":[{"value":"2016-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}