{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T17:56:05Z","timestamp":1695578165474},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,30]],"date-time":"2017-05-30T00:00:00Z","timestamp":1496102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>In registration studies, combination therapy of paritaprevir\/ritonavir, ombitasvir, and dasabuvir (PrOD) with and without ribavirin for 12\u201324\u00a0weeks can achieve &gt;\u00a090% sustained virological response (SVR) for genotype 1 hepatitis C virus (HCV) infection. However, data in Asia is scanty. We aimed to study the efficacy and safety of this combination therapy in chronic hepatitis C patients in Hong Kong.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data from six local hospitals that have prescribed PrOD with and without ribavirin to patients with genotype 1 chronic HCV infection as part of a global compassionate program.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 41 patients treated, 35 (85%) patients had genotype 1b HCV infection, 6 (15%) had co\u2010infection with human immunodeficiency virus, 35 (85%) failed previous peginterferon and ribavirin therapy, 25 (61%) had compensated liver cirrhosis, and 3 (7%) had liver transplantation. Thirty\u2010five (85%) patients received 12\u2010week treatment and six patients received 24\u2010week treatment; 26 (63%) patients received ribavirin combination. Thirty\u2010nine (95%; 95% confidence interval 88.5\u2013100%) patients had undetectable HCV RNA at 12\u2010week post\u2010treatment, that is, SVR. The two patients who did not develop SVR discontinued treatment prematurely; both of them were treatment experienced with liver cirrhosis complicated by acute renal failure unrelated to the treatment of PrOD and ribavirin. No patient had hepatic decompensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Paritaprevir\/ritonavir, ombitasvir, and dasabuvir with or without ribavirin is effective and safe in patients with genotype 1 HCV infection in real\u2010life clinical setting in Hong Kong.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13663","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T11:26:39Z","timestamp":1479727599000},"page":"1230-1233","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Real\u2010life efficacy and safety of paritaprevir\/ritonavir, ombitasvir, and dasabuvir in chronic hepatitis C patients in Hong Kong"],"prefix":"10.1111","volume":"32","author":[{"given":"Henry Lik\u2010Yuen","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics and Institute of Digestive Disease The Chinese University of Hong Kong  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen Tak\u2010Yin","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics Princess Margaret Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee\u2010Tak","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Medicine Queen Elizabeth Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of Hong Kong Queen Mary Hospital  Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace Chung\u2010Yan","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics and Institute of Digestive Disease The Chinese University of Hong Kong  Hong 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