{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T04:26:10Z","timestamp":1774671970382,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The epidemiology of coeliac disease (CD) is changing. Presentation of CD with malabsorptive symptoms or malnutrition is now the exception rather than the rule and, it now affects those underweight and overweight equally. In concert with these epidemiological shifts, the incidence of CD is increasing. These changing patterns of disease presentation are challenging traditional management paradigms, and clinicians now need to adapt to these changes and respond to the demands of an increasingly well\u2010informed consumer population. This article aims to provide historical context to the epidemiological changes in CD, which provides context to direct future research.<\/jats:p><jats:p>Changing definitions and diagnostic paradigms are complicating the management of CD. The gold standard of diagnosis, treatment goals, guidelines for follow\u2010up, and the role of population screening in CD remain controversial and unresolved. Although the patient population is interested in new treatments for CD and alternatives to a gluten\u2010free diet, most therapies are not yet widely available or sufficiently researched, and our understanding of the natural history of CD is limited despite a number of retrospective and population\u2010based studies. The management of asymptomatic CD has only recently been examined despite up to half of patients now presenting with no or minimal symptoms.<\/jats:p><jats:p>There is surprisingly little evidence to resolve many of these issues, and only with robust prospective studies will our understanding of the true natural history of coeliac disease be clarified.<\/jats:p>","DOI":"10.1111\/jgh.13704","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T10:21:15Z","timestamp":1488277275000},"page":"82-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Coeliac disease in the 21st century: paradigm shifts in the modern age"],"prefix":"10.1111","volume":"32","author":[{"given":"Evan D","family":"Newnham","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Eastern Health Clinical School Monash University  Box Hill Hospital, Box Hill Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5909.45"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1953.tb05586.x"},{"key":"e_1_2_6_4_1","first-page":"17","article-title":"On the coeliac affection","volume":"24","author":"Gee S","year":"1888","journal-title":"St. Bartholomew Hospital Rep."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.17.8.612"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.21"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.10"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.13060"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2006.00659.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12018"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04053.x"},{"issue":"1","key":"e_1_2_6_12_1","first-page":"63","article-title":"High prevalence of undiagnosed coeliac disease in adults: a Swedish population\u2010based study","volume":"245","author":"Ivarsson A","year":"1999","journal-title":"J. Intern. Med. Blackwell Science Ltd"},{"key":"e_1_2_6_13_1","volume-title":"Principles and Practice of Screening for Disease","author":"Wilson JMG","year":"1968"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-159-3-201308060-00006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.3.333"},{"issue":"1","key":"e_1_2_6_17_1","first-page":"1","article-title":"A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways","volume":"11","author":"Anderson RP","year":"2013","journal-title":"BMC Medicine. BMC Medicine"},{"issue":"1","key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1471-2431-14-165","article-title":"Body mass index is not a reliable tool in predicting celiac disease in children","volume":"14","author":"Pals M","year":"2014","journal-title":"BMC Pediatrics. BioMed Central Ltd"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3765"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12510"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903555879"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.051"},{"key":"e_1_2_6_23_1","unstructured":"NewnhamED ShepherdSJ GibsonPR.A phase II randomised double\u2010blind placebo\u2010controlled study to evaluate the efficacy and safety of oral effervescent budesonide in the induction of mucosal healing in newly diagnosed coeliac disease: Australia and New Zealand Clinical Trials Registry: ACTRN12609000738224 [Internet].anzctr.org.au. [cited2014Nov 21]. Available from:https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=308403"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X13492580"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.105"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313977"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0101428"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.12.032"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.026708"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-014-0752-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107312"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/elan.201000583"}],"container-title":["Journal of Gastroenterology and Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgh.13704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgh.13704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T10:42:56Z","timestamp":1695638576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jgh.13704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,28]]},"references-count":31,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1111\/jgh.13704"],"URL":"https:\/\/doi.org\/10.1111\/jgh.13704","archive":["Portico"],"relation":{},"ISSN":["0815-9319","1440-1746"],"issn-type":[{"value":"0815-9319","type":"print"},{"value":"1440-1746","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,28]]},"assertion":[{"value":"2016-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}