{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:10:29Z","timestamp":1787314229419,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T00:00:00Z","timestamp":1488240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Irritable bowel syndrome\u2010like symptoms in response to wheat ingestion is common and well described, but whether the reaction is due to gluten (i.e., non\u2010coeliac gluten sensitivity), other wheat proteins, or FODMAPs (mostly fructans) alone or in combinations has not been clearly defined. Exclusion of coeliac disease in the presence of negative serology, and normal villous architecture but increased density of intraepithelial lymphocytes on duodenal biopsies, is difficult. Furthermore, the confidence by which a positive diagnosis is made or non\u2010coeliac gluten sensitivity is excluded by blinded placebo\u2010controlled rechallenge with wheat protein is reduced by strong nocebo responses generally found in patients with self\u2010reported non\u2010coeliac gluten sensitivity. The absence of a clear biological mechanism of action and difficulties with the design and interpretation of research studies have plunged this entity into even deeper controversy. In the absence of clarity in its diagnosis, the epidemiology, prognosis, and therapeutic approaches to a patient who may be gluten sensitive remain to be determined. Adequate understanding of the issues surrounding the controversy and further research will slowly unravel the truth behind the problem.<\/jats:p>","DOI":"10.1111\/jgh.13705","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T05:21:15Z","timestamp":1488259275000},"page":"86-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Non\u2010coeliac gluten sensitivity"],"prefix":"10.1111","volume":"32","author":[{"given":"Peter R","family":"Gibson","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Monash University and Alfred Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gry I","family":"Skodje","sequence":"additional","affiliation":[{"name":"Department of Nutrition Research University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut E A","family":"Lundin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5103839"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980014000652"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.meg.0000435546.87251.f7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","unstructured":"GibsonPR MuirJG NewnhamED.Other dietary confounders: FODMAPS et al. 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