{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:58:48Z","timestamp":1789520328224,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T00:00:00Z","timestamp":1498089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Little is known about how to include adults &lt;\u00a050\u00a0years in colonoscopy screening. This study aimed to derive a risk\u2010scoring model incorporating laboratory indicators for metabolic risks to predict advanced colorectal neoplasia (ACN) in asymptomatic Korean adults both younger and older than 50\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 70\u00a0812 consecutive adult recipients of a screening colonoscopy in a single health check\u2010up center in Korea between 2003 and 2012 were enrolled. A risk score model was developed using multiple logistic regression model and internally validated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall prevalence of ACN was 1.4% (956\/70\u00a0812). A 15\u2010point score model was developed to comprise age, sex, family history of colorectal cancer, smoking, body mass index, serum levels of fasting glucose, low\u2010density lipoprotein cholesterol, and carcinoembryonic antigen. Based on the score, the validation cohort could be categorized into five risk groups (low, borderline, moderate, high, and very high) with an ACN prevalence of 0.7%, 1.3%, 2.7%, 6.6%, and 13.2%, respectively. Compared with the borderline risk group, the low\u2010risk group showed a 50.3% reduced risk of ACN. Meanwhile, the moderate, high, and very high risk groups showed 2, 5, and 10\u2010fold increased risk of ACN. The score showed significantly superior discriminative power than the Asian\u2010Pacific colorectal screening score (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our scoring model based on both clinical and laboratory risk factors is useful for the prediction of ACN. This score may be used to include adults &lt;\u00a050\u00a0years in colonoscopy screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13711","type":"journal-article","created":{"date-parts":[[2016,12,25]],"date-time":"2016-12-25T05:11:40Z","timestamp":1482642700000},"page":"1328-1335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Derivation and validation of a risk scoring model to predict advanced colorectal neoplasm in adults of all ages"],"prefix":"10.1111","volume":"32","author":[{"given":"Hyo\u2010Joon","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine and Gastrointestinal Cancer Center, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungkyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in 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