{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T18:08:12Z","timestamp":1781374092581,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T00:00:00Z","timestamp":1501200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>We evaluated associations of esophagogastric junction (EGJ) metrics as an anti\u2010reflux barrier with impedance\u2013pH, endoscopic esophagitis, and lower esophageal sphincter (LES) metrics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed high\u2010resolution manometry data from consecutive patients with gastroesophageal reflux disease (GERD) symptoms who underwent impedance\u2013pH and endoscopy, and asymptomatic volunteers. The EGJ contractile integral (CI) was calculated as the mean contractile integral\/second during three respiratory cycles. EGJ morphology was classified according to LES\u2013crural diaphragm (CD) separation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 137 patients (65 male, age 55\u00a0years) and 23 (9 male, age 33\u00a0years) controls were enrolled. Twenty\u2010five patients had erosive reflux disease (ERD), 16 had non\u2010erosive reflux disease (NERD), 5 had reflux hypersensitivity, and 91 were not GERD. EGJ\u2010CI were lower in patients with GERD (22.6 [13.8\u201329.2]\u00a0mmHg cm) than non\u2010GERD (50.3 [31\u201369.9] mmHg cm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and controls (67 [26.7\u201378.7] mmHg cm). With an EGJ\u2010CI cut\u2010off value of 30\u00a0mmHg cm, the area under the curve was 0.814 (0.762\u20130.896), with 77.8% sensitivity and 81.7% specificity for the prediction of GERD. LES\u2013CD separation was greatest in patients with ERD, followed the NERD, non\u2010GERD, and controls. EGJ morphology type III was associated with a higher DeMeester score (7.9 [1.6\u201312.6]) than were type II (3.25 [0.9\u20135.975]) and I (1.75 [0.8\u20136.2]; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). EGJ\u2010CI values were lower in patients with GERD than in others in each EGJ morphology subgroup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Esophagogastric junction contractile integral showed good diagnostic accuracy with high specificity in predicting GERD. LES\u2013CD separation is associated with an increase in acid reflux, but EGJ\u2010CI was associated more strongly with GERD than was EGJ morphology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13720","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T19:42:41Z","timestamp":1483731761000},"page":"1443-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Esophagogastric junction contractile integral and morphology: Two high\u2010resolution manometry metrics of the anti\u2010reflux barrier"],"prefix":"10.1111","volume":"32","author":[{"given":"Hyoju","family":"Ham","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Bae","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul\u2010Hyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Myung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010Gyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703273361306"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.8.1020"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.11.008"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12267"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12638"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12757"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12477"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01138.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.012"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12389"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12611"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2011.08.007"},{"key":"e_1_2_5_14_1","first-page":"241","article-title":"Pathophysiology of gastro\u2010oesophageal reflux disease","volume":"26","author":"De Giorgi F","year":"2006","journal-title":"Acta Otorhinolaryngol. 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