{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T07:58:39Z","timestamp":1791964719953,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T00:00:00Z","timestamp":1503878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The aim of this study was to assess the effectiveness of yttrium\u201090 (<jats:sup>90<\/jats:sup>Y) microspheres for the treatment of unresectable metastatic liver neuroendocrine tumors (NET).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From February 2006 to September 2015, 36 patients (19 male and 17 female, age 63.6\u00a0\u00b1\u00a09.4\u00a0years) who underwent <jats:sup>90<\/jats:sup>Y therapy for unresectable liver metastases of NET were included and analyzed retrospectively. All patients received a variety of treatments before <jats:sup>90<\/jats:sup>Y therapy. The radiological response, symptoms improvement of carcinoid syndrome, tumor marker changes, complications, side effects\/toxicity, survival, and factors related to survival were evaluated and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 36 patients, the mean delivered dose of <jats:sup>90<\/jats:sup>Y was 1.8\u00a0\u00b1\u00a00.7\u00a0GBq with a total of 40 treatments. Overall disease control rate was 88.9% (32\/36) at 3\u00a0months following therapy. In 16 patients with carcinoid syndrome, 15 (93.8%) patients had symptomatic improvement. Tumor marker response (5\u2010hydroxyindoleacetic acid [<jats:italic>n<\/jats:italic>\u00a0=\u00a07] and chromogranin A [<jats:italic>n<\/jats:italic>\u00a0=\u00a013]) at 3\u00a0months after treatment were as follows: none (<jats:italic>n<\/jats:italic>\u00a0=\u00a00, 4), partial (<jats:italic>n<\/jats:italic>\u00a0=\u00a06, 7), and complete (<jats:italic>n<\/jats:italic>\u00a0=\u00a01, 2). Radiation\u2010induced gastrointestinal ulcers (<jats:italic>n<\/jats:italic>\u00a0=\u00a02, 5.6%) were identified. Side effects included fatigue (<jats:italic>n<\/jats:italic>\u00a0=\u00a031, 86.1%), anorexia (<jats:italic>n<\/jats:italic>\u00a0=\u00a026, 72.2%), nausea (<jats:italic>n<\/jats:italic>\u00a0=\u00a015, 41.7%), vomiting (<jats:italic>n<\/jats:italic>\u00a0=\u00a014, 38.9%), abdominal pain (<jats:italic>n<\/jats:italic>\u00a0=\u00a010, 27.8%), and fever (<jats:italic>n<\/jats:italic>\u00a0=\u00a08, 22.2%). The mean follow\u2010up was 27.0\u00a0\u00b1\u00a016.4\u00a0months, with a median survival of 41.0\u00a0months. Child\u2013Pugh classification (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.008) and lymph node metastases (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.045) had statistically significant influence on overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Yttrium\u201090 radioembolization can be effective in the treatment of unresectable liver metastases of NET who failed to respond to other treatments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13752","type":"journal-article","created":{"date-parts":[[2017,1,29]],"date-time":"2017-01-29T23:23:06Z","timestamp":1485732186000},"page":"1617-1623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Single\u2010institution experience of radioembolization with yttrium\u201090 microspheres for unresectable metastatic neuroendocrine liver tumors"],"prefix":"10.1111","volume":"32","author":[{"given":"Zhongzhi","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Interventional Radiology The Second People's Hospital of Changzhou, Nanjing Medical University  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Paz\u2010Fumagalli","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Sella","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Mark","family":"McKinney","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e3181ec124e"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.12.022"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01017"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi358"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.RVI.0000232177.57950.71"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31815e4557"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443612"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6468"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s00330-002-1558-0","article-title":"Trans\u2010catheter arterial chemoembolization as first\u2010line treatment for hepatic metastases from endocrine tumors","volume":"13","author":"Roche A","year":"2003","journal-title":"Eur. 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