{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:17:26Z","timestamp":1791393446484,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Transient elastography is the reference method for liver stiffness measurement (LSM) in the general population, having lower applicability in obese patients. We evaluated the applicability and diagnostic accuracy of the M and XL probes in overweight\/obese patients to establish the most appropriate approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From May 2013 to March 2015, we evaluated patients with a body mass index (BMI) \u2265\u00a028\u00a0kg\/m<jats:sup>2<\/jats:sup>. We constructed an algorithm with variables independently related to unreliable LSM with the M probe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1084 patients were evaluated. M and XL probe applicability was 88.8% and 98%, respectively. Waist circumference (WC) (OR; 95% CI; <jats:italic>P<\/jats:italic>) (0.97; 0.94\u20130.99; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and skin\u2010capsule distance (SCD) (0.83; 0.79\u20130.87; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) were independently related to unreliable LSM (M probe). The SCD was &gt;\u00a025\u00a0mm in 5.5% of individuals with a BMI \u2264\u00a035\u00a0kg\/m<jats:sup>2<\/jats:sup> and a WC \u2264\u00a0117\u00a0cm, with LSM (M probe) applicability rising to 94.3%. In contrast, 36.9% of patients with a BMI &gt;\u00a035\u00a0kg\/m<jats:sup>2<\/jats:sup> and\/or a WC &gt;\u00a0117\u00a0cm presented an SCD &gt;\u00a025\u00a0mm, with M probe applicability being 73.1%. The diagnostic accuracy (area under the receiver operator characteristic) using the M probe to identify significant steatosis (0.76), fibrosis (0.89), and cirrhosis (0.96) was very high in patients with a BMI \u2264\u00a035\u00a0kg\/m<jats:sup>2<\/jats:sup> and a WC \u2264\u00a0117\u00a0cm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The applicability and accuracy of the FibroScan<jats:sup>\u00ae<\/jats:sup> M probe to identify fibrosis and steatosis was excellent in overweight and obesity grade I (BMI \u2264\u00a035\u00a0kg\/m<jats:sup>2<\/jats:sup>) with a WC \u2264\u00a0117\u00a0cm. The XL probe increased the applicability of transient elastography in obesity grade II\u2013III (BMI &gt;\u00a035\u00a0kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13762","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T22:32:44Z","timestamp":1487197964000},"page":"1746-1753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Impact of anthropometric features on the applicability and accuracy of FibroScan<sup>\u00ae<\/sup> (M and XL) in overweight\/obese patients"],"prefix":"10.1111","volume":"32","author":[{"given":"Marc","family":"Puigveh\u00ed","sequence":"first","affiliation":[{"name":"Liver Section, Gastroenterology Department Hospital del Mar  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona 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Spain"},{"name":"Department of Medicine Universitat Autonoma  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Liver Section, Gastroenterology Department Hospital del Mar  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Liver Section, Gastroenterology Department Hospital del Mar  Barcelona Spain"},{"name":"IMIM (Hospital del Mar Medical Research Institute)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital del Mar  Barcelona 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