{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T06:27:55Z","timestamp":1762324075184,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control & Prevention","doi-asserted-by":"publisher","award":["2016\u2010E63001\u201000"],"award-info":[{"award-number":["2016\u2010E63001\u201000"]}],"id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Gastro and Hepatol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The present study evaluated the clinical characteristics of Korean patients with Crohn's disease (CD) according to their age at diagnosis in a nationwide multicenter cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1224 patients diagnosed with CD between 1982 and 2008 in 32 hospitals were included, and age at diagnosis was categorized as \u2264\u00a016 (G1), 17\u201340 (G2), 41\u201359 (G3) and \u2265\u00a060 (G4) years old. The baseline characteristics, medication, and intestinal resection were compared according to the age at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of patients in each age group was 155 (G1; 12.7%), 919 (G2; 75.1%), 120 (G3; 9.8%), and 30 (G4; 2.5%). The frequencies of ileocolonic disease in the late adult onset and elderly onset groups were lower than those in the other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The cumulative probabilities of thiopurine and anti\u2010tumor necrosis factor use in late adult onset and elderly onset groups were significantly reduced compared with those of the other groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). However, the risk of the first intestinal resection was not different among the age groups. The ileal location (hazard ratio [HR]: 1.59; 95% confidence interval [CI]: 1.11\u20132.27), complicated behavior (HR: 3.35; 95% CI: 2.63\u20134.27), and early thiopurine use (HR: 0.27; 95% CI: 0.17\u20130.43) were associated with the first intestinal resection, whereas the age at diagnosis was not a risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Elderly onset CD may be related to favorable outcomes in Korea. Thus, the heterogeneity of this disease should be considered when developing a tailored strategy for the treatment of CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jgh.13775","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T05:36:48Z","timestamp":1488433008000},"page":"1716-1722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Influence of age at diagnosis on the clinical characteristics of Crohn's disease in Korea: Results from the CONNECT study"],"prefix":"10.1111","volume":"32","author":[{"given":"Sung Wook","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"},{"name":"Department of Gastroenterology University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-6345","authenticated-orcid":false,"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Pil","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byong Duk","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoon Sup","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konyang University College of Medicine  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Chan","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Konyang University College of Medicine  Daejeon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hee","family":"Cheon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inje University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Soo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hanyang University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Crohn's disease 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